Abstract
A 14-year-old boy had persistent haematuria along with complete C7 deficiency. No significant changes in glomeruli and tubules were found in a renal biopsy specimen by light microscopy and immunofluorescence gave negative results for immune deposits. Electron microscopic examination demonstrated an attenuation of the glomerular capillary basement membrane without lamination and a diagnosis of thin basement membrane disease was made. It would be difficult to conclude that patients with C7 deficiency were predisposed to develop glomerulonephritis caused by immunologic aberrations. A family study failed to provide evidence of an association of C7 deficiency and thin basement membrane disease.
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Abbreviations
- SLE:
-
systemic lopus erythematosus
- CHSØ:
-
haemolytic complement
References
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Sakano, T., Hamasaki, T., Mori, M. et al. C7 deficiency and persistent haematuria. Eur J Pediatr 147, 516–517 (1988). https://doi.org/10.1007/BF00441978
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DOI: https://doi.org/10.1007/BF00441978