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Can high-dose immunoglobulin therapy be indicated in neonatal rhesus haemolysis?

A successful case of haemolytic disease due to rhesus (c+E) incompatibility

  • Neonatology
  • Published:
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Abstract

A male neonate with hyperbilirubinaemia and progressing anaemia due to rhesus (c+E) incompatibility received high dose intravenous gammaglobulin (ivIgG) therapy at 13 days of age. Clinical response to therapy was confirmed by a rapid decrease in serum bilirubin level, and with the prevention of a further decline of the haemoglobin level. No side-effects were noted. High dose ivIgG therapy could be an alternative to (exchange) blood transfusion in case of some haemolytic diseases of newborn.

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Abbreviations

ivIgG:

high-dose intravenous gammaglobulin

HND:

haemolytic disease of newborn

Rh:

rhesus

References

  1. Berkman SA, Lee ML, Gale RP (1990) Clinical use of intravenous immunoglobulins. Ann Int Med 112:278–292

    PubMed  Google Scholar 

  2. Berlin G, Selbing A, Ryden G (1985) Rhesus haemolytic disease treated with high-dose intravenous immunoglobulin. Lancet I:1153

    Article  Google Scholar 

  3. Camara CDL, Arrieta R, Gonzalez A, Iglesias E, Omenaka F (1988) High-dose intravenous immunoglobulin as the sole prenatal treatment for severe Rh immunization. N Engl J Med 318: 519–520

    PubMed  Google Scholar 

  4. Derycke M, Dreyfus M, Ropert JC, Tchernia G (1985) Intravenous immunoglobulin for neonatal isoimmune thrombocytopenia. Arch Dis Child 60:667–669

    PubMed  Google Scholar 

  5. Hara T, Mizuno Y, Kawano M, Ueki Y, Ueda K (1987) Treatment of immune hemolytic anemia with gammaglobulin. J Pediatr 110:817–818

    PubMed  Google Scholar 

  6. Oda H, Honda A, Sugita K, Nakamura A, Nakajima H (1985) High-dose intravenous intact IgG infusion in refractory autoimmune hemolytic anemia (Evans syndrome). J Pediatr 107:744–746

    PubMed  Google Scholar 

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Kubo, S., Ariga, T., Tsuneta, H. et al. Can high-dose immunoglobulin therapy be indicated in neonatal rhesus haemolysis?. Eur J Pediatr 150, 507–508 (1991). https://doi.org/10.1007/BF01958434

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  • DOI: https://doi.org/10.1007/BF01958434

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