Abstract
Over a period of 4 years, 88 infants with cow's milk protein intolerance (CMPI) were followed prospectively in order to evaluate the persistence of CMPI and its relationship between either serum IgE levels or RAST results for cow's milk. After exclusion of lactose intolerance, two positive cow's milk elimination challenge tests were considered diagnostic for CMPI. At the age of 1, 2, 3 and 4 years respectively, 85%, 78%, 49% and 33% of the children still were cow's milk intolerant. Initial serum values of IgE ≥10 kU/l indicated a late development of tolerance to cow' milk proteins. At the age of 4 years, 90% of infants with initial IgE levels <10 k U/l had become tolerant to cow's milk while this was the case for only 47% of infants with initial IgE levels ≥10 k U/l. Initial RAST results for cow's milk bore no obvious relationship to outcome.
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Abbreviations
- CMPI:
-
cow's milk protein intolerance
References
Bahna SL, Heiner C (1980) Allergies to milk. Grun and Stratton, New York
Bishop JM, Hill DJ, Hosking CS (1990) Natural history of cow's milk allergy: clinical outcome. J Pediatr 116:862–867
Bock SA (1987) Prospective appraisal of complaints of adverse reactions to foods in children during the first 3 years of life. Pediatrics 79:683–688
Businco L, Benincori N, Cantani A, Tacconi L, Picarazzi A (1975) Chronic diarrhea due to cow's milk intolerance. Arch Dis Child 50:351–354
Clein NW (1958) Cow's milk allergy in infants and children. Int Arch Allergy 1–3:245–256
Dockhorn RJ (1987) Clinical studies of foodallergy in infants and children. Ann Allergy 59:137–140
Gerrard JW, MacKenzie JWA, Goluboff N, Garson JZ, Maningas CS (1973) Cow's milk allergy: prevalence and manifestations in an unselected series of newborns. Acta Paediatr Scand [Suppl]234:1
Goldman AS, Anderson DW, Sellers WA, Saperstein S, Kniker WT, Halpern SR (1963) Oral challenge with milk and isolated milk proteins in allergic children. Pediatrics 32:425–443
Hill DJ, Davidson GP, Cameron DJS, Barnes GL (1979) The spectrum of cow's milk allergy in childhood. Acta Paediatr Scand 68:847–852
Hill DJ, Firer MA, Ball G, Hosking CS (1989) Recovery from milk allergy in early childhood. Antibody studies. J Pediatr 114:761–766
Ishizaka K, Ishizaka T, Hornbrook MM (1966) Physiochemical properties of human reagenic antibody: IV Presence of a unique immunoglobulin as a carrier of reagenic activity. J Immunol 97:75–79
Jakobson I, Lindberg T (1979) A prospective study of cow's milk protein intolerance in swedish infants. Acta Paediatr Scand 68:853–859
Kjellman N-IM (1976) Immunoglobulin E and atopic allergy in childhood. Linkoping University Medical Dissertions 36
Kjellman N-IM (1976) Predictive value of high IgE levels in children. Acta Paediatr Scand 65:465–471
Kjellmann N-IM, Bjorkstein B, Hattevig G, Falth-Magnusson K (1988) Natural history of food allergy. Ann Allergy 61:83–87
Kletter B, Gerry I, Freier S, Noah Z, Davies MA (1971) Immunoglobublin E antibodies to milk proteins. Clin Allergy 1:249–255
Kuitunen P, Visakorpi JK, Savilahti E, Pelkonen P (1975) Malabsorption syndrome with cow's milk intolerance. Arch Dis Child 50:351–356
Lindberg RE, Arroyave PhD (1986) Levels of IgE in serum from normal children and allergic children as measured by an enzyme immunoassay. J Allergy Clin Immunol 78:614–618
Rzany B, Jarisch R, Gotz M (1986) Spezifische IgE-Antikörper gegen Kuhmilchproteine bei Kindern mit Verdacht auf Kuhmilch Allergie. Monatsschr Kinderheilkd 134:799–803
Sampson HA, Scanlon SM (1989) Natural history of food hypersensitivity in children with atopic dermatitis. J Pediatr 115:23–26
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Schrander, J.J.P., Oudsen, S., Forget, P.P. et al. Follow up study of cow's milk protein intolerant infants. Eur J Pediatr 151, 783–785 (1992). https://doi.org/10.1007/BF01959091
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DOI: https://doi.org/10.1007/BF01959091