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The possible risk of bilirubin encephalopathy as predicted by plasma parameters in neonates with previous severe asphyxia

  • Neonatology
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Abstract

The study group consisted of nine mature newborn infants with a previous history of severe asphyxia and a control group of 18 mature, healthy newborns with the same postnatal age and sex. The object of the investigation was to compare the possible risk of development of bilirubin encephalopathy between the two groups as estimated by plasma parameters. The asphyxia group had a significantly lower reserve albumin concentrations for binding of monoacetyldiaminodiphenyl sulphone (P=0.008), a measure of binding of unconjugated bilirubin, and significantly lower total albumin concentrations (P=0.02). No significant difference was observed in unconjugated bilirubin concentration. It is suggested that mature newborns with previous severe asphyxia are at a slightly increased risk of developing bilirubin encephalopathy over and above the well-known risk associated with increased permeability of the blood brain barrier.

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Abbreviations

MADDS:

monoacetyldiaminodiphenyl sulphone

References

  1. Brodersen R (1974) Competetive binding of bilirubin and drugs to human serum albumin studied by enzymatic oxidation. J Clin Invest 54:1353–1358

    PubMed  Google Scholar 

  2. Brodersen R (1978) Binding of bilirubin and other ligands to human albumin. In: Peters T, Sjöholm I (eds) Albumin structure, biosynthesis, and function. Pergamond Press, New York, Oxford, p 61–70

    Google Scholar 

  3. Brodersen R, Bartels P (1969) Enzymatic oxidation of bilirubin. Eur J Biochem 10:468–473

    Article  PubMed  Google Scholar 

  4. Brodersen R, Andersen S, Jacobsen C, Sönderskov O, Ebbesen F, Cashore W, Larsen S (1982) Determination of infant serum reserve albumin for binding of bilirubin, using a selective trace-ligand. Anal Biochem 121:395–408

    Article  PubMed  Google Scholar 

  5. Brown A, McDonagh A (1980) Phototherapy for neonatal hyperbilirubinemia: Efficacy, mechanism and toxicity. Adv Pediatr 27:341–381

    PubMed  Google Scholar 

  6. Eriksen E, Danielsen H, Brodersen R (1981) Bilirubin-liposome interaction: formation of a bilirubin dianion—phospholipid complex, followed by protonization and bilirubin acid aggregation. J Biol Chem 256:4269–4274

    PubMed  Google Scholar 

  7. Esbjörner E, Larsson P, Leissner P, Wranne L (1991) The serum reserve albumin concentration for monoacetyldiaminodiphenyl sulphone and auditory evoked responses during neonatal hyperbilirubinemia. Acta Paediatr Scand 80:406–412

    PubMed  Google Scholar 

  8. Gartner LM, Sugden RN, Chabon RS, Bernstein J (1970) Kernicterus: High incidence in premature infants with low serum bilirubin concentrations Pediatrics 45:906–917

    PubMed  Google Scholar 

  9. Hill P, Wells T (1983) Bromeresol purple and the measurement of albumin. Ann Clin Biochem 20:264–270

    PubMed  Google Scholar 

  10. Ho C-K, Robertson AF, Karp WB (1985) Hematin and bilirubin binding to human serum albumin and newborn serum. Acta Paediatr Scand 74:372–377

    PubMed  Google Scholar 

  11. Holle B, Bönnelycke K, Kemp E, Mortensen LT (1983) Motoric—perceptual development. Palsvig K, Vedel-Petersen J, Porsborg M (eds) Munksgaard, Copenhagen

    Google Scholar 

  12. Ito U, Go K, Walker J, Spatz M, Klatzo I (1976) Experimental cerebral ischemia in mongolian gerbils. III Behavior of the blood-brain barrier. Acta Neuropathol 34:1–6

    Article  PubMed  Google Scholar 

  13. Jendrassik L, Gróf P (1938) Vereinfachte photometrische Methoden zur Bestimmung des Blutbilirubins. Z Biochem 297: 81–89

    Google Scholar 

  14. Johnson L, Boggs TR (1974) Bilirubin-dependent brain damage: Incidence and indications for treatment. In: Odell GB, Schaffer R, Simopoulos AP (eds) Phototherapy in the newborn: an overview. National Academy of Sciences, Washington DC, p 122–149

    Google Scholar 

  15. Lou HC, Tweed WA, Johnson G, Jones M, Lassen NA (1977) Breakdown of the blood-brain barrier in kernicterus. Lancet I:1062

    Article  Google Scholar 

  16. Lucey JF, Hibbard E, Behrman R, Gallardo FD, Windle WF (1964) Kernicterus in asphyxiated newborn rhesus monkeys. Exp Neurol 9:43–58

    Article  Google Scholar 

  17. Sarnat HB, Sarnat MS (1975) Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 33:696–705

    Google Scholar 

  18. Stern L, Denton RL (1965) Kernicterus in small premature infants. Pediatrics 35:483–485

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics, University Hospital of Aalborg, DK-9000, Denmark

    F. Ebbesen & A. Knudsen

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  1. F. Ebbesen
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  2. A. Knudsen
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Ebbesen, F., Knudsen, A. The possible risk of bilirubin encephalopathy as predicted by plasma parameters in neonates with previous severe asphyxia. Eur J Pediatr 151, 910–912 (1992). https://doi.org/10.1007/BF01954128

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  • DOI: https://doi.org/10.1007/BF01954128

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