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Results of selective screening for inborn errors of metabolism in the former East Germany

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Abstract

Since the early 1970s selective screening for inherited metabolic disorders has been performed in larger childrens hospitals or metabolic centres of the former East-Germany. As a rule the following methods were employed: initially paper chromatography, drop, dip and spot tests, later on thin-layer chromatography and more recently enzyme analysis, gas chromatography, mass spectrometry and HPLC. Normally urine, blood or leucocytes were investigated. The diagnoses were confirmed in metabolic centres in Greifswald, Berlin or Leipzig or in collaboration with specialized laboratories abroad. About 130000 subjects from former East Germany as well as from different East European countries were investigated, of which 365 patients were diagnosed and classified into roughly 40 various metabolic diseases. The proportion of positive diagnoses was 1 in 400.

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References

  1. Knapp A, Machill G (1974) Screening auf angeborene Stoffwechselkrankheiten. Kinderärztl Prax 42: 270–277

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Authors and Affiliations

  1. Medizinische Fakultät, Institut für Medizinische Genetik, Ernst-Moritz-Arndt-Universität Greifswald, Fleischmannstrasse 42/44, D-17487, Greifswald, Germany

    G. Machill, U. Grimm, G. Seidlitz & T. Schneider

  2. Kinderklinik, Humboldt-Universität Berlin, Charité, Schumannstrasse 20/21, D-10117, Berlin, Germany

    Ingrid Ahlbehrendt

  3. Kinderklinik, Universität Leipzig, Medizinische Fakultät, Oststrasse 20-25, D-04317, Leipzig, Germany

    P. Bührdel & Annelore Naumann

  4. Institut für Biochemie, Universität Leipzig, Medizinische Fakultät, Liebigstrasse, D-04103, Leipzig, Germany

    H. J. Böhme

  5. Medizinische Fakultät, Kinderklinik, Universität Rostock, Rembrandtstrasse 16-17, D-18055, Rostock, Germany

    W. Tittelbach-Helmrich

Authors
  1. G. Machill
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  2. U. Grimm
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  3. Ingrid Ahlbehrendt
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  4. P. Bührdel
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  5. W. Tittelbach-Helmrich
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  6. Annelore Naumann
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  7. H. J. Böhme
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  8. G. Seidlitz
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  9. T. Schneider
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Machill, G., Grimm, U., Ahlbehrendt, I. et al. Results of selective screening for inborn errors of metabolism in the former East Germany. Eur J Pediatr 153 (Suppl 1), S14–S16 (1994). https://doi.org/10.1007/BF02138771

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  • DOI: https://doi.org/10.1007/BF02138771

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