Skip to main content
SpringerLink
Log in

Omphalocele in a newborn baby exposed to sodium valproate in utero

  • Medical Genetics
  • Original Paper
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

We report on a newborn baby, exposed to valproic acid in utero, with the typical dysmorphic features of the fetal valproate syndrome and omphalocele. One identical case has already been reported after valproic acid exposure in utero.

Conclusion

Intra-uterine valproate exposure may be responsible for midline defects of the abdominal wall.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

VPA :

valproic acid

References

  1. Ardinger H, Atkin J, Blackston D, Elsas L, Clarren S, Livingstone S, Flanery D, Pellock J, Harrod M, Lammer E, Majewski F, Schinzel A, Toriello H, Hanson J (1988) Verification of the fetal valproate syndrome phenotype. Am J Med Genet 29:171–185

    Article  PubMed  Google Scholar 

  2. Bantz E (1983) Valproic acid and congenital malformations, a case report. Clin Pediatr 23:352–353

    Google Scholar 

  3. Cotariu D, Zardman JL (1991) Developmental toxicity of valproic acid. Life Sci 48:1341–1350

    Article  PubMed  Google Scholar 

  4. Di Liberti J, Farndon H, Dennio N, Curry C (1984) The fetal valproate syndrome Am J Med Genet 19:473–481

    Article  PubMed  Google Scholar 

  5. Felding I, Rane A (1984) Congenital liver damage after treatment of mother with valproic acid and phenitoin. Acta Paediatr Scand 73:565–568

    PubMed  Google Scholar 

  6. Jager-Romän E, Derchl A, Jakob S, Hartman AM, Koch S, Rating D, Steldinger R, Nau H, Helge H (1986) Fetal growth, major malformations and minor anomalies in infants born to women receiving valproic acid. J Pediatr 108:997–1004

    PubMed  Google Scholar 

  7. Lammer E, Sever L, Oakley G (1987) Teratogen upadate: valproic acid. Teratology 35:465–473

    Article  PubMed  Google Scholar 

  8. Martincz-Frias ML (1990) Clinical manifestation of prenatal exposure to valproic acid using case reports and epidemtologic information. Am J Med Genet 37:277–282

    Article  PubMed  Google Scholar 

  9. Naruse I, Collins M, Scott W (1988) Strain differences in the teratogenicity induced by sodium valproate in cultured mouse embryos. Teratology 38: 87–96

    Article  PubMed  Google Scholar 

  10. Petrere J, Anderson J, Sakowski R, Fitzgerald J De La, Iglesia F (1986) Teratogenesis of calcium valproate in rabbits. Teratology 34:263–269

    Article  PubMed  Google Scholar 

  11. Robert E, Guilbaud P (1982) Maternal valproic acid and congenital neural tube defects. Lancet II:1142

    Google Scholar 

  12. Winter RM, Donnai D, Burn J, Tuckers SM (1987) Fetal valproate syndrome: is there a recognisable phenotype? J Med Genet 29:692–695

    Google Scholar 

  13. Winter RM, Knowles SAS, Bieber FR, Baraitser M (1988) The malformed fetus and stillbirth: a diagnostic ap proach. john Wiley and Sons, New York, pp 136–137

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre Hospitalier, Universitaire de Poitiers, B.P. 577, F-86021, Poitiers Cedex, France

    T. Boussemart, D. Bonneau, M. Berthier & D. Oriot

  2. Unité Fonctionnelle de Chirurgie Infantile, Centre Hospitalier, Universitaire de Poitiers, France

    G. Levard

Authors
  1. T. Boussemart
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Bonneau
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Berthier
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. Oriot
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Levard
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Boussemart, T., Bonneau, D., Berthier, M. et al. Omphalocele in a newborn baby exposed to sodium valproate in utero. Eur J Pediatr 154, 220–221 (1995). https://doi.org/10.1007/BF01954275

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01954275

Key words

Search

Navigation