Summary
Rat brain tumor was used as a model to evaluate radiation therapy with and without misonidazole. BD-IX rats were implanted intracerebrally with an ethylnitrosourea-induced glioma. Three series of experiments were performed, with radiation given 14 days after inoculation of the glioma clone. In each series, the following radiation doses were given: 500 rads once, 1,000 rads once; and 1,000 rads twice, every time with or without two different doses of misonidazole. Radiation therapy significantly prolonged survival when compared to the longevity of the control group. The dose of 1,000 rads given twice was highly effective and the life-span of tumor-bearing rats increased from 72% to 121%. Misonidazole plus irradiation negated the prolongation of survival, achieved with radiation therapy alone.
Similar content being viewed by others
References
Atkins HL, Seaman WB, Jacox HW, Matteo RS (1965) Experience with hyperbaric oxygenation in clinical radiotherapy. Am J Roentogenol 93:651–663
Chang CH (1977) Hyperbaric oxygen and radiation therapy in the management of glioblastoma. In: Modern concept in brain tumor therapy; laboratory and clinical investigations. National Cancer Institute Monograph 46, Bethesda, pp 163–169
Du Sault LA (1963) The effect of oxygen on the response of spontaneous tumours in mice to radiotherapy. Br J Radiolol 36:749–754
Edelman FL, Aleu F, Scheinberg LC et al. (1964) Effect of irradiation on the growth of intracerebral gliomas in mice. J Neuropathol Exp Neurol 23:1–17
Gray HL, Conger AD, Ebert M, Hornsey B, Scot OCA (1953) The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 26:638–648
Mennel HD, Groneck P (1977) Quantitative aspect of transplantation of experimentally induced tumors of the nervous system. Acta Neuropathol (Berl) 40:145–150
Phillips TL (1977) Chemical modification of radiation effects. Cancer 39 (Suppl):987–999
Sheldon PW, Hill SA (1977) Hypoxic cell sensitizer and local control by X-ray of a transplanted tumour in mice. Br J Cancer 35:795–808
Sheldon PW, Hill SA (1977) Further investigations of the effects of the hypoxic-cell radiosensitizer, Ro-07-0582, on local control of a mouse tumour. Br J Cancer 36:198–205
Sheldon PW, Foster JL, Fowler JF (1974) Radiosensitization of C3H mouse mammary tumours by a 2-nitroimidazole drug. Br J Cancer 30:560–565
Steinbok P, Mahaley MS, Jr, Raymond U, Zinn DC, Lipper S, Mahaley JL, Bigner DD (1979) Synergism between BCNU and irradiation in the treatment of anaplastic gliomas. J Neurosurg 51:581–586
Tamura M, Mennel HD, Zülch KJ (1979) Brain tumor chemotherapy using a rat glioma model. J Cancer Res Clin Oncol 94:39–46
Tator CH, Wasserman W, So WS (1977) Therapy of an experimental glioma with systemic or intraneoplastic methotrexate or radiation. J Neurosurg 46:175–184
Weber E (1976) Unabhangige Stichproben. In: Weber E (ed) Grundriß der biologischen Statistik. G. Fischer, Stuttgart, pp 501–505
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tamura, M., Inoue, H., Murata, M. et al. Radiation therapy of rat brain tumor using misonidazole as hypoxic cell sensitizer. J Cancer Res Clin Oncol 109, 188–192 (1985). https://doi.org/10.1007/BF00390355
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00390355