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Experimentelle Untersuchungen zur Chemosensibilität von Impftumoren bei unterschiedlicher Transplantationslokalisation

Experimental investigations about the chemosensibility of transplantation tumors at different sites of transplantation

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Summary

The inoculation of transplantation tumors at different sites resulted in different chemotherapeutic responses to cyclophosphamide. For the Yoshida-sarcoma, depending on the inoculation sites, the chemosensitivity after application of 10 mg/kg cyclophosphamide decreased in this order: subcutis, lung, muscle, peritoneal cavity, kidney, brain.

Zusammenfassung

Nach Transplantation von Impftumoren an verschiedene Lokalisationen ergab sich eine unterschiedliche Chemosensibilität gegenüber Cyclophosphamid. Beim Yoshida Sarkom nahm die Chemosensibilität nach Gabe von 10 mg/kg in Abhängigkeit vom Transplantationsort wie folgt ab: Subcutis, Hoden, Lunge, Muskulatur, Bauchhöhle, Niere, Gehirn.

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Literatur

  • Bonmassar,E., Castagnone,D., Celi,M.L., Melan,F.: Interferenza di fattori immunologici sull'attivita antitumorale della sarcolysina. Arch. Ital. Patol. Clin. Tumori 11, 215–228 (1968).

    Google Scholar 

  • —, Cudkowicz,G., Vladamudi,S., Goldin,A.: Influence of tumor-host differences at a single histocompatibility locus (H-1) on the antileukemic effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC 40 9962). Cancer Res. 30, 2538–2542 (1970).

    Google Scholar 

  • Ferrer,J.F., Mihich,E.: Dependence of the regression of sarcoma 180 in vitamin B6-deficient mice upon the immunologic competence of the host. Cancer Res. 27, 456–461 (1967).

    Google Scholar 

  • Gerhards,H.J., Graul,E.H.: Autoradiographische Untersuchungen über die Verteilung von 3H-Cyclophosphamid in der Ratte. Arzneim.-Forsch. 20, 601–607 (1970).

    Google Scholar 

  • Henderson,J.F.: Variation in selective toxicity; causes and consequences. Cancer Res. 29, 2404 (1969).

    Google Scholar 

  • Mihich,E.: Combined effects of chemotherapy and immunity against Leukemia L 1210 in DBA 12 Mice. Cancer Res. 29, 848–854 (1969).

    Google Scholar 

  • Sato,R.: Host resistance against tumor and its synergystic effect with cancer chemotherapy. Gann 58, 211–220 (1967).

    Google Scholar 

  • Schmähl,D., Mecke,R.: Quantitative Transplantationsversuche mit dem Yoshida-Aszitessarkom der Ratte. Z. Krebsforsch. 60, 711–729 (1955).

    Google Scholar 

  • —, Rieseberg,T.: Experimentelle Untersuchungen an Ratten über die Metastasierung von Tumoren. Z. Krebsforsch. 62, 456–480 (1958).

    Google Scholar 

  • —, Osswald,H., Prochotta,L.: Quantitative Untersuchungen an Ratten über die Resistenz verschiedener Organe gegen inoculierte Tumorzellen. Z. Krebsforsch. 70, 130–137 (1967).

    Google Scholar 

  • —, Entstehung, Wachstum und Chemotherapie maligner Tumoren, 2. Aufl. Aulendorf: Ed. Cantor 1970.

    Google Scholar 

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Authors and Affiliations

  1. Institut für exp. Toxikologie und Chemotherapie am Deutschen Krebsforschungszentrum Heidelberg, Bundesrepublik Deutschland

    E. Holst, U. Sievers & D. Schmähl

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  1. E. Holst
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  2. U. Sievers
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  3. D. Schmähl
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Holst, E., Sievers, U. & Schmähl, D. Experimentelle Untersuchungen zur Chemosensibilität von Impftumoren bei unterschiedlicher Transplantationslokalisation. Z. Krebsforsch. 76, 325–329 (1971). https://doi.org/10.1007/BF00304035

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  • DOI: https://doi.org/10.1007/BF00304035

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