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Spontantumoren des syrischen Goldhamsters

Spontaneous tumors in Syrian Golden Hamsters

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Summary

From results of a long-term experiment with 3605 Syrian Golden Hamsters treated with carcinogenic substances and/or cigarette smoke, the problem of spontaneous tumors is discussed. Histologically the tumors are compared with tumors in man. Several tumors, e. g., of the adrenals, may be explained by genetic factors. Results of experiments prove that the hamster is suitable for testing inhalable carcinogenic substances.

Zusammenfassung

Anhand eines größeren Untersuchungsgutes von insgesamt 3605 syrischen Goldhamstern, die im Verlauf eines Langzeitversuches mit Carcinogenen und/oder Zigarettenrauch behandelt wurden, wird das Problem der spontanen Tumorhäufigkeit diskutiert. Die Tumoren werden im Hinblick auf die histologische Struktur mit Tumoren des Mentchen verglichen. Bei einzelnen Tumoren, z. B. der Nebenniere wurden genetische Faktoren als wesentliche Ursache angesehen. Aufgrund der Ergebnisse konnte festgestellt werden, daß der Hamster sich offenbar besonders gut für Experimente zur Testung inhalierbarer Carcinogene eignet.

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Authors and Affiliations

  1. Forschungsinstitut der Cigarettenindustrie e. V., Hamburg

    W. Dontenwill, H. -J. Chevalier, H. -P. Harke, U. Lafrenz & G. Reckzeh

  2. Medizinische Hochschule Hannover, Institut für Biometrie und Medizinische Informatik, Bundesrepublik Deutschland

    B. Schneider

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  1. W. Dontenwill
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  2. H. -J. Chevalier
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  3. H. -P. Harke
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  4. U. Lafrenz
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Die Veröffentlichung wurde durch Unterstützung des Forschungsinstitutes der Cigaretten-Industrie e.V. ermöglicht.

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Dontenwill, W., Chevalier, H.J., Harke, H.P. et al. Spontantumoren des syrischen Goldhamsters. Z. Krebsforsch. 80, 127–158 (1973). https://doi.org/10.1007/BF00305131

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