Summary
The effects of dietary polychlorinated biphenyls (PCBs) on hepatocarcinogenesis in female rats of Donryu strain receiving 3′-methyl-4-dimethyl-aminoazobenzene (3′-Me-DAB) were investigated. Oral administration of PCBs after administration of 3′-Me-DAB resulted in a high incidence (64%) of hepatocarcinoma. In contrast, administration of a similar amount of PCBs before, or together with 3′-Me-DAB did not induce hepatic tumors. Administration of a slightly larger amount of PCBs alone did not induce liver tumors, while administration of a slightly larger amount of 3′-Me-DAB alone caused only a low incidence (13%) of hepatocarcinoma. These results strongly suggest that PCBs exert a potent promoting action in experimental azo dye hepatocarcinogenesis.
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This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education and from the Ministry of Health and Welfare, Japan
The authors thank Prof. K. Tanaka for gift of Kanechlor-400, and for treating the excreta to prevent environmental pollution by PCBs
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Kimura, N.T., Kanematsu, T. & Baba, T. Polychlorinated biphenyl(s) as a promotor in experimental hepatocarcinogenesis in rats. Z. Krebsforsch. 87, 257–266 (1976). https://doi.org/10.1007/BF00506498
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DOI: https://doi.org/10.1007/BF00506498