Summary
Serial studies by endoscopy and biopsy were made in a Beagle dog during and after oral administration of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). Between the 23rd and the 45th week of observation erosions and ulcers appeared at the angulus of the stomach and turned into ulcer scar. A depression with atypical glands was seen in the ulcer scar of the posterior wall of the angulus at the 94th week. It developed elevated margins at the 102nd week, when a well differentiated adenocarcinoma was found histopathologically. Ulceration and reepithelialization were observed in the early carcinoma. The carcinoma progressed into a larger one of Borrmann's type 2 at the 115th week and further into its type 3 at the 181st week. A second carcinoma with signet ring cell carcinoma developed in the anterior wall of the angulus. The two carcinomas fused and formed a single lesion. At autopsy in the 216th week the carcinoma invaded the serosa, and metastasis to regional lymph nodes was observed.
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Supported by grants from the Ministry of Education, Science, and Culture, the Ministry of Health and Welfare, and Nakayama Foundation in Japan
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Saito, T., Sasaki, O., Iwamatsu, M. et al. Experimental gastric carcinoma induced by N-methyl-N′-nitro-N-nitrosoguanidine. J Cancer Res Clin Oncol 97, 51–62 (1980). https://doi.org/10.1007/BF00411278
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DOI: https://doi.org/10.1007/BF00411278