Summary
A chronic uremic syndrome was induced by 5/6 nephrectomy and an acute uremic syndrome by bilateral nephrectomy in rats.
In the chronic uremic syndrome serum and urine analysis revealed a highly increased serum level of BUN and creatinine. Furthermore, all chemical signs typical of secondary hyperparathyroidism were present. The animals suffered from severe polyuria, protein- and albuminuria but, surprisingly, the total serum protein was increased. The experimental chronic uremic syndrome is, in essence, a syndrome of “extreme adaptation” of the regulatory activity of remnant renal parenchyma and of the whole body.
In contrast, the acute uremic syndrome induced by bilateral nephrectomy is a severe disorder of water and electrolyte metabolism resulting in death of the experimental animals after 50–60 hrs.
Zusammenfassung
Durch eine 5/6-Nierenparenchymreduktion wurde an Ratten ein chronisches, durch bilaterale Nephrektomie ein akutes urämisches Syndrom erzeugt.
Beim chronischen urämischen Syndrom erwiesen sich in der Serumanalyse die Konzentrationen des Harnstoffstickstoffs und des Kreatinins als wesentlich erhöht. Darüber hinaus bestanden alle chemischen Zeichen eines sekundären Hyperparathyreoidismus. Die Tiere litten außerdem an einer schweren Poly-, Protein- und Albuminurie. Überraschenderweise war aber der Spiegel des totalen Serumproteins gegenüber den Kontrolltieren erhöht. Das experimentelle chronische urämische Syndrom stellt eine extreme Adaptation der regulatorischen Aktivität des Nierenrestparenchyms und des ganzen Organismus dar.
Beim akuten, durch bilaterale Nephrektomie erzeugten urämischen Syndrom besteht dagegen ein schweres Versagen der Regulation des Wasser- und Elektrolytstoffwechsels, welches innert 50–60 Std zum Tode der Versuchstiere führt.
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Abbreviations
- BUN:
-
Blood Urea Nitrogen
- SGPT:
-
Serum-Glutamate-Pyruvate-Transaminase
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Heitz, P., Ohnacker, H. & Meier, P. Experimental uremic syndrome in the rat. Res. Exp. Med. 163, 341–349 (1974). https://doi.org/10.1007/BF01851521
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DOI: https://doi.org/10.1007/BF01851521
Key words
- Experimental uremic syndrome
- Rat
- 5/6 reduction of renal parenchyma
- Serum- and urine analysis
- Secondary hyperparathyroidism