Summary
The finding of several examples of Hb E Saskatoon in the Orkney Islands, in Edinburgh and in individuals of Scottish descent in Canada but nowhere else, suggests that the original mutation occurred in Scotland, perhaps in the Orkneys.
References
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Vella, F., Labossiere, A., Wiltshire, B., Lehmann, H., Shojania, A. M., Hill, J. R.: The occurrence of hemoglobins E and E Saskatoon in Central Canada. Amer. J. clin. Path. 60, 314–318 (1973)
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Tills, D., Muir, V., Warlow, A. et al. The occurrence of Hb E Saskatoon in Scotland. Hum Genet 33, 179–180 (1976). https://doi.org/10.1007/BF00281893
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DOI: https://doi.org/10.1007/BF00281893