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Sequences which flank an 11p deletion observed in an hepatocellular carcinoma map to 11p13

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Summary

There is considerable interest in the 11p13 region because of its involvement in Wilms tumor, sporadic aniridia, and other congenital abnormalities. Cloned DNA sequences from this region might be useful in understanding the chromosomal abnormalities which lead to such disorders. However, few such markers exist. Using somatic cell hybrids which contain defined 11p deletions, two cloned DNA sequences which flank a deletion generated in an hepatocellular carcinoma (as a consequence of hepatitis B virus integration) were mapped to 11p13. Thus both ends of the deletion observed in an hepatocellular carcinoma are within 11p13.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Pulmonary Diseases, Section Human Genetics, Webb Waring Lung Institute, Eleanor Roosevelt Institute for Cancer Research, University of Colorado, Health Sciences Center, 4200 E. Ninth Avenue, 80262, Denver, CO, USA

    J. H. Fisher & C. H. Scoggin

  2. Department of Medicine, Albert Einstein College of Medicine, 10461, Bronx, NY, USA

    C. E. Rogler

Authors
  1. J. H. Fisher
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  2. C. H. Scoggin
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  3. C. E. Rogler
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Fisher, J.H., Scoggin, C.H. & Rogler, C.E. Sequences which flank an 11p deletion observed in an hepatocellular carcinoma map to 11p13. Hum Genet 75, 66–69 (1987). https://doi.org/10.1007/BF00273842

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  • DOI: https://doi.org/10.1007/BF00273842

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