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Autosomal recessive and dominant forms of polycystic kidney disease are not allelic

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Summary

Linkage analysis has been carried out in 11 kindreds with autosomal recessive polycystic kidney disease (ARPKD) using the genetic marker 3'HVR, closely linked (\(\hat \theta = 0.05\)) to the gene of the autosomal dominant type. Close linkage (\(\hat \theta \leqq 0.20\)) between the locus of the marker and that of ARPKD can be excluded. These data strongly suggest that the loci for the autosomal recessive and dominant forms of polycystic kidney disease are not allelic.

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Authors and Affiliations

  1. Institut für Humangenetik der Universität, Wilhelmstrasse 31, D-5300, Bonn 1, Germany

    Brunhilde Wirth, K. Zerres & A. Gal

  2. Hopital de Hautpierre, Avenue Molière, F-67200, Strasbourg, France

    M. Fischbach & J. Geisert

  3. Kinderklinik der Universität, Im Neuenheimer Feld 150, D-6900, Heidelberg, Germany

    Dorothea Claus & D. E. Müller-Wiefel

  4. Medizinische Klinik der Universität, Hugstetter Strasse 55, D-7800, Freiburg, Germany

    H. P. H. Neumann

  5. Kinderklinik Charlottenburg, Freie Universität, Heubnerweg 6, D-1000, Berlin 19

    T. Lennert

  6. Kinderklinik der Medizinischen Hochschule, Konstanty-Gutschow-Strasse 8, D-3000, Hannover 61, Germany

    J. Brodehl

  7. Institut für Medizinische Statistik der Universität, Sigmund-Freud-Strasse 25, D-5300, Bonn, Germany

    M. Neugebauer

Authors
  1. Brunhilde Wirth
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  2. K. Zerres
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  3. M. Fischbach
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  4. Dorothea Claus
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  5. H. P. H. Neumann
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  6. T. Lennert
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  7. J. Brodehl
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  8. M. Neugebauer
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  9. D. E. Müller-Wiefel
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  10. J. Geisert
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  11. A. Gal
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Wirth, B., Zerres, K., Fischbach, M. et al. Autosomal recessive and dominant forms of polycystic kidney disease are not allelic. Hum Genet 77, 221–222 (1987). https://doi.org/10.1007/BF00284473

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  • DOI: https://doi.org/10.1007/BF00284473

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