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Relationships between DNA and protein polymorphisms of apolipoprotein B

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Summary

The associations between four restriction fragment length polymorphisms (RFLPs) of the gene for human apolipoprotein B (apo B) and five antigen group (Ag) protein-polymorphisms of apo B have been investigated in 24 unrelated Finnish individuals. In this sample a complete correlation exists between the EcoRI RFLP and the Ag(t/z) polymorphism. There is strong association between the alleles of the XbaI RFLP and Ag(c/g) and a weaker one of the same XbaI site with Ag(x/y). Linkage disequilibrium is observed between the PvuII RFLP and the Ag(a1/d) polymorphism. These associations confirm that the Ag variants are true protein sequence polymorphisms of apo B.

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Authors and Affiliations

  1. Charing Cross Sunley Research Centre, Lurgan Avenue, Hammersmith, W6 8LW, London, UK

    Alison M. Dunning & Steve E. Humphries

  2. Third Department of Medicine, University of Helsinki, SF-00290, Helsinki, Finland

    Matti J. Tikkanen

  3. National Public Health Institute, SF-00 280, Helsinki, Finland

    Christian Ehnholm

  4. Central Laboratory, Blood Transfusion Service of the Swiss Red Cross, CH-3000, Berne 22, Switzerland

    René Bütler

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  1. Alison M. Dunning
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  2. Matti J. Tikkanen
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  3. Christian Ehnholm
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  4. René Bütler
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  5. Steve E. Humphries
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Dunning, A.M., Tikkanen, M.J., Ehnholm, C. et al. Relationships between DNA and protein polymorphisms of apolipoprotein B. Hum Genet 78, 325–329 (1988). https://doi.org/10.1007/BF00291728

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  • DOI: https://doi.org/10.1007/BF00291728

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