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Human αB-crystallin (CRYA2) gene mapped to chromosome 11q12-q23

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Summary

The αB-crystallin gene (CRYA2) encodes the abundant lens protein αB-crystallin. A panel of human/ rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster αB-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q12-11q23.

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Authors and Affiliations

  1. Department of Molecular Biology and Cell Biology, University of Nijmegen, Toernooiveld, NL-6525, ED Nijmegen, The Netherlands

    Ruud H. Brakenhoff & John G. G. Schoenmakers

  2. Department of Human Genetics, University of Nijmegen, P. O. Box 9101, NL-6500, HB Nijmegen, The Netherlands

    Ad H. M. Geurts van Kessel

  3. Department of Biochemistry, University of Nijmegen, P. O. Box 9101, NL-6500, HB Nijmegen, The Netherlands

    Hans Bloemendal

  4. Institute of Human Genetics, Sylvius Laboratoria of the University of Leiden, P. O. Box 9503, NL-2300, RA Leiden, The Netherlands

    Margot Oldenburg, Jules T. Wijnen & P. Meera Khan

Authors
  1. Ruud H. Brakenhoff
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  2. Ad H. M. Geurts van Kessel
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  3. Margot Oldenburg
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  4. Jules T. Wijnen
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  5. Hans Bloemendal
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  6. P. Meera Khan
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  7. John G. G. Schoenmakers
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Brakenhoff, R.H., van Kessel, A.H.M.G., Oldenburg, M. et al. Human αB-crystallin (CRYA2) gene mapped to chromosome 11q12-q23. Hum Genet 85, 237–240 (1990). https://doi.org/10.1007/BF00193203

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  • DOI: https://doi.org/10.1007/BF00193203

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