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The physical map of chromosome arm 19q: some new assignments, confirmations and re-assessments

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Summary

We have constructed and analysed somatic cell hybrids from cell lines containing balanced reciprocal translocations involving chromosome 19 and providing two new breakpoints on 19q. These and other hybrids have been tested with a series of markers from 19q to enhance the existing map. Several new cloned DNA sequences that map to 19q13.3–19qter are reported; the locus D19Z1 has been analysed by CHEF gel electrophoresis.

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Author notes

  1. J. D. Brook

    Present address: Center for Cancer Research, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA

Authors and Affiliations

  1. Institute of Medical Genetics, University of Wales College of Medicine, CF4 4XN, Heath Park, Cardiff, UK

    J. D. Brook, S. J. L. Knight, S. H. Roberts, H. G. Harley, K. V. Walsh, S. A. Rundle, K. Freyne, M. C. Koch & D. J. Shaw

  2. Clinical Haematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, 20892, Bethesda, MD, USA

    N. D. Epstein

  3. Department of Human Genetics, University of Nijmegen, Radboud Hospital, P.O.Box 9101, NL-6500 HB, Nijmegen, The Netherlands

    B. Wieringa, D. Schonk & H. Smeets

  4. Department of Microbiology, University of Reading, London Road, RG1 5AQ, Reading, UK

    K. Haddingham

  5. Department of Genetics, University of Texas, M. D. Anderson Hospital and Tumor Institute, TX 77030, Houston, USA

    M. J. Siciliano

  6. Florence R. Sabin Laboratories, Eleanor Roosevelt Institute for Cancer Research, Inc., 4200 East 9th Avenue B-129, 80262, Denver, CO, USA

    D. K. Palmer

  7. Imperial Cancer Research Fund, Laboratory of Molecular Pharmacology and Drug Metabolism, University Department of Biochemistry, Hugh Robson Building, George Square, EH8 9XD, Edinburgh, UK

    J. S. Miles & C. R. Wolf

  8. Institut für Genetik, Medizinische Hochschule, Karl-Wiechert-Allee 9, W-3000, Hannover 61, Germany

    C. Fonatsch

Authors
  1. J. D. Brook
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  2. S. J. L. Knight
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  3. S. H. Roberts
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  4. H. G. Harley
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  5. K. V. Walsh
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  6. S. A. Rundle
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  7. K. Freyne
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  8. M. C. Koch
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  9. N. D. Epstein
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  10. B. Wieringa
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  11. D. Schonk
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  12. H. Smeets
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  13. K. Haddingham
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  14. M. J. Siciliano
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  15. D. K. Palmer
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  16. J. S. Miles
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  17. C. R. Wolf
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  18. C. Fonatsch
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  19. D. J. Shaw
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Brook, J.D., Knight, S.J.L., Roberts, S.H. et al. The physical map of chromosome arm 19q: some new assignments, confirmations and re-assessments. Hum Genet 87, 65–72 (1991). https://doi.org/10.1007/BF01213095

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  • DOI: https://doi.org/10.1007/BF01213095

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