Summary
Porcine thyroid cells were cultured alone or in mixed cultures with mesenchymal cells. The formation of a basal lamina in vitro was investigated ultrastructurally. Follicular reassociation of thyroid cells occurred in both types of culture; however, it was followed by formation of the basal lamina only when mesenchymal cells were present. The present findings suggest an epithelial origin of the basal lamina resulting from an interaction with mesenchymal cells.
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The authors wish to thank Mrs. J. Bottini for skillful preparation of the manuscript. This study was supported by the CNRS-ERA n∘ 322 and by INSERM-CRL n∘ 75 50394
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Alquier, C., Fayet, G., Hovsepian, S. et al. Biosynthesis of the basal lamina as a result of interaction between thyroid and mesenchymal cells in culture. Cell Tissue Res. 200, 69–81 (1979). https://doi.org/10.1007/BF00236888
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DOI: https://doi.org/10.1007/BF00236888