Summary
The response of the Juxtaglomerular apparatus to bilateral adrenalectomy was studied in rats. After the sixth postoperative day, symptoms of severe adrenal insufficiency had developed. In the Juxtaglomerular cells, the volume density of the secretory granules decreased from 32% to 16%. The Golgi apparatus and rough endoplasmic reticulum underwent considerable proliferation, the latter showing strikingly enlarged cisternae.
Zusammenfassung
Die Reaktion des juxtaglomerulären Apparates auf Adrenalektomie wurde untersucht. Im Stadium der Nebenniereninsuffizienz, sechs Tage nach der Operation, wurde quantitativ morphometrisch eine Abnahme der Volumendichte der Sekretgranula (von 32% auf 16%) festgestellt. Golgi-Apparat und Ergastoplasma proliferieren stark, wobei insbesondere die erweiterten Cisternen des Ergastoplasmas auffallen.
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Supported by “Deutsche Forschungsgemeinschaft” (SFB 90, “Cardiovasculäres System”).-The authors wish to acknowledge the valuable assistance of Miss K. Kahl in helping in the clinical care of the rats. The technical assistance and ability of Miss. C. Dénéréaz was a great help for the electron microscopy.
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Peter, S., Lazar, J., Gross, F. et al. Studies on the juxtaglomerular apparatus. Cell Tissue Res. 151, 457–469 (1974). https://doi.org/10.1007/BF00222991
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DOI: https://doi.org/10.1007/BF00222991