Summary
Histological observation on the mesenteric lymph node and Peyer's patches of C3H B mice, neonatally thymectomized, lethally irradiated and reconstituted with syngeneic bone marrow cells, showed that a large number of lymphocytes appeared selectively in the restricted territory surrounding the post-capillary venules. Severe depletion of lymphocytes persisted in most of the thymus-dependent areas. Lymphocytes were also observed passing through the walls of the post-capillary venules. Autoradiographic studies on the mesenteric lymph node of recipient B mice 30 minutes after intravenous injection of cells labelled with 3H-uridine and taken from lymph nodes of donor B mice showed that B lymphocytes could penetrate the walls of the post-capillary venules from the blood into the peripheral lymphoid tissues. The post-capillary venules, which are known as the recirculating route of T lymphocytes in normal animals, are thought to be the pathway of migrating B lymphocytes in B mice.
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This work was supported by a grant for Scientific Research from the Japanese Ministry of Education.
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Kotani, M., Nawa, Y., Fujii, H. et al. Post-capillary venules as the pathway for migrating B lymphocytes. Cell Tissue Res. 152, 299–303 (1974). https://doi.org/10.1007/BF00223952
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DOI: https://doi.org/10.1007/BF00223952