Summary
The ultrastructure of the neurosecretory cells in the paraventricular nucleus of the normal male rat was studied by electron microscopy during various functional states. Four morphologically distinct types of neurosecretory cells were observed. It appears that they do not represent different classes of cells but different phases of secretory activity of a single cell type. The perikarya of the neurosecretory cells show a definite cycle of formation and transportation of secretory granules. We have designated the phases of this cycle as: (1) phase of synthesis, (2) phase of granule production, (3) phase of granule storage and (4) phase of granule transport. The neurosecretory granules appear to be moved in bulk into the axons, forming a large axonal swelling filled with granules as a result of one cycle in the neurosecretory process. Thus it may be postulated that a secretory cycle in the perikaryon of the neurosecretory cell seems to result in the formation of a Herring body in its axon, and that its content is then conveyed to the posterior pituitary.
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References
Bargmann, W.: Structure and function of neurosecretory systems. Triangle 3, 207–217 (1958)
Bargmann, W., Knoop, A.: Über die morphologischen Beziehungen des neurosekretorischen Zwischenhirnsystems zum Zwischenlappen der Hypophyse (licht-und elektronenmikroskopische Untersuchungen). Z. Zellforsch. 52, 256–277 (1960)
Bodian, D.: Cytological aspects of neurosecretion in opposum neurohypophysis. Bull. Johns Hopk. Hosp. 113, 57–93 (1963)
Bodian, D.: Herring bodies and neuroapocrine secretion in the monkey. An electron microscopic study of the fate of the neurosecretory product. Bull. Johns Hopk. Hosp. 118, 282–326 (1966)
Dellmann, H.-D., Rodríguez, E.M.: Herring bodies; an electron microscopic study of local degeneration and regeneration of neurosecretory axons. Z. Zellforsch. 111, 293–315 (1970)
Farquhar, M.G., Rinehart, J.F.: Electron microscopic studies of the anterior pituitary gland of castrate rats. Endocrinology 54, 516–541 (1954)
Hartmann, J.F.: Electron microscopy of the neurohypophysis in normal and histamine-treated rats. Z. Zellforsch. 48, 291–308 (1958)
Jamieson, J.D., Palade, G.E.: Intracellular transport of secretory proteins in the pancreatic exocrine cell. I. Role of the peripheral elements of the Golgi complex. J. Cell Biol. 34, 577–596 (1967)
Kurosumi, K.: Functional classification of cell types of the anterior pituitary gland accomplished by electron microscopy. Arch. histol. jap. 29, 329–362 (1968)
Kurosumi, K.: Ultrastructure of the rat posterior pituitary gland, with special reference to the release mechanism of the neurosecretory substance. Med. J. Osaka Univ. 21, 53–73 (1971)
Polenov, A.L., Garlov, P.E.: The hypothalamo-hypophysial system in Acipenseridae. I. Ultrastructural organization of large neurosecretory terminals (Herring bodies) and axoventricular contacts. Z. Zellforsch. 116, 349–374 (1971)
Weibel, E.R.: Stereological principles for morphometry in electron microscopic cytology. Int. Rev. Cytol. 26, 235–302 (1969)
Zambrano, D., Mordoh, J.: Neurosecretory activity in supraoptic nucleus of normal rats. Z. Zellforsch. 73, 405–413 (1966)
Zambrano, D., Robertis, E. de: The secretory cycle of supraoptic neurons in the rat. Z. Zellforsch. 73, 414–431 (1966)
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Yukitake, Y., Taniguchi, Y. & Kurosumi, K. Ultrastructural studies on the secretory cycle of the neurosecretory cells and the formation of herring bodies in the paraventricular nucleus of the rat. Cell Tissue Res. 177, 1–8 (1977). https://doi.org/10.1007/BF00221114
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DOI: https://doi.org/10.1007/BF00221114