Summary
Previous clinical studies have indicated that during pregnancy and following administration of contraceptives women show altered carbohydrate metabolism. We performed autoradiographic studies using 3H-estradiol-17β and 3H-dihydrotestosterone on male and female baboons. Discrete sites of localization of exposed photographic emulsion were observed over nuclei of cells of the islets of Langerhans of the pancreases of baboons injected with estrogen but not over those of baboons injected with androgen. These observations that islet cells contain specific receptors for estrogen when combined with the clinical observations, suggest that estrogens have a direct effect on the islet cells that may modulate the release of insulin.
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References
Buchler D, Warren JC (1966) Effects of estrogen on glucose tolerance. Am J Obstet Gyn 95:479–483
Clark SA, Stumpf WE, Sar M, De Luca HF, Tanaka Y (1980) Target cells for 1,25 dihydroxyvitamin D3 in the pancreas. Cell Tissue Res 209:515–520
Cohn E (1971) Oral contraceptive agents and the glucose tolerance problem. Pa Med 74:62–64
Costrini NV, Kalkhoff RK (1971) Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion. J Clin Invest 50:992–999
Faure A, Sutter-Dub M-Th (1979) Insulin secretion from isolated pancreatic islets in the female rat. J Physiol (Paris) 75:289–295
Gorski J, Gannon F (1976) Current models of steroid hormone action: a critique. In: Knobil E, Sonnenschium RR, Edelman IS (eds) Annual reviews of physiology. Annual Reviews Inc, Palo Alto, Calif, p 425–450
Howell SL, Tyhurst M, Green IC (1977) Direct effects of progesterone on rat islets of Langerhans in vivo and in tissue culture. Diabetologia 13:579–583
Ison EJ, Sheridan PJ (1981) Autoradiography of diffusible substances — a practical approach. Am J Med Tech 47:38–42
Javier Z, Gershberg H, Hulse M (1968) Ovulatory suppressants, estrogens, and carbohydrate metabolism. Metabolism 17:443–456
Leake RE (1981) Problems associated with dose response in steroid-hormone activation of structural genes. Mol and Cell Endocrinol 21:1–13
Lenzen S (1978) Effects of Ovariectomy and treatment with progesterone or oestradiol-17β on the secretion of insulin by the perfused rat pancreas. J Endocrinol 78:153–154
McGill HC, Sheridan PJ (1981) Nuclear uptake of sex steroid hormones in the cardiovascular system of the baboon. Circ Res 48:238–244
Rosenthal HE, Sandberg AA (1978) Estrogen binding proteins in rat pancreas. J Steroid Biochemistry 9:1133–1139
Sandberg AA, Rosenthal HE (1979) Steroid receptors in exocrine glands: the pancreas and prostate. J Steroid Biochemistry 11:293–299
Siegel S (1956) Non-parametric statistics for the behavioral sciences. McGraw-Hill, New York, pp 75:83–14
Stumpf WE (1971) Autoradiographic techniques for the localization of hormones and drugs at the cellular and sub-cellular level. Acta Endocrinology [KBH] 9suppl) 153:205–221
Sutter-Dub M-Th (1976) Preliminary report: effects of female sex hormones on insulin secretion by the perfused rat pancreas. J Physiol (Paris) 72:795–800
Sutter-Dub M-Th (1979) Effects of pregnancy and progesterone and/or oestradiol on the insulin secretion and pancreatic insulin content in the perfused rat pancreas. Diab Metab 5:47–56
Tesone M, Chazenbalk GD, Ballejos G, Charreau EJ (1979) Estrogen receptors in rat pancreatic islets. J Steroid Biochemistry 11:1309–1314
Tyson JE, Feiig P (1971) Medical aspects of diabetes in pregnancy and the diabetogenic effects of oral contraceptives. Med Clinics of North America 55:947–959
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Winborn, W.B., Sheridan, P.J. & McGill, H.C. Estrogen receptors in the islets of Langerhans of baboons. Cell Tissue Res. 230, 219–223 (1983). https://doi.org/10.1007/BF00216041
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DOI: https://doi.org/10.1007/BF00216041