Abstract
Some patients with hypercalciuria are thought to have enhanced enteric calcium absorption, with a major component of recent diet contributing to urinary calcium. This mechanism has been difficult to test with the usual calcium loading procedures. We employed dual stable calcium isotope tracers to quantitate the components of urinary calcium excretion in 38 healthy female children. The mean urinary calcium excretion in these girls was 2.4 mg/kg per day. The contribution of recent diet to this total was a mean of 0.2 mg/kg per day. The maximum dietary contribution to urinary calcium excretion was 0.86 mg/kg per day. Recent diet contributes a mean of 8% to total dietary calcium excretion. This novel method permits precise quantitation of the contributions of recent diet and tissue stores to urinary calcium excretion. In these healthy girls, the fraction of urinary calcium derived from diet is trivial.
Similar content being viewed by others
References
Coe FL, Parks JH, Moore ES (1979) Familial idiopathic hypercalciuria. N Engl J Med 300:337–340
Morduchowicz GA, Goodman WG, Lee DBN (1989) Divalent ion metabolism. Curr Nephrol 12:229–262
Matkovic V, Fontana D, Tominac C, Goel P, Chesnut CH (1990) Factors that influence peak bone mass formation: a study of calcium balance and the inheritance of bone mass in adolescent females. Am J Clin Nutr 52:878–888
Canniggia A, Gennari C, Cesari L (1965) Nutritional absorption of45Ca in stone-forming patients. BMJ 1:427
Pak CYC, Kaplan R, Bone H, Townsend J, Waters O (1975) A simple test for the diagnosis of absorptive, resorptive and renal bypercalciurias. N Engl J Med 292:497–500
Ratovitz J, Miller LA, Stapleton FB (1992) Dietary sodium and the diagnosis of hypercalciuria. Pediatr Res 31:339A
Hillman LS, Tack E, Covell DG, Vieira NE, Yergey AL (1988) Measurement of true calcium absorption in premature infants using intravenous46Ca and oral44Ca. Pediatr Res 23:589–594
Shoemaker LS, Welch TR, Bergstrom W, Abrams SA, Yergey AL, Vieira N (1993) Calcium kinetics in the hyperprostaglandin E syndrome. Pediatr Res 33:92–96
Yergey AL, Vieira NE, Hansen JW (1980) Isotope ratio measurements of urinary calcium with a thermal ionization probe in a quadrupole mass spectometer. Anal Chem 52:1811–1814
Coe FL (1977) Treated and untreated recurrent calcium nephrolithiasis in patients with idiopathic hypercalciuria, hyperuricuria, and no metabolic disorder. Ann Intern Med 87:404–410
Thomas WC Jr (1990) Urinary calculi in hypercalcemic states. Endocrinol Metab Clin North Am 19:839–849
Coe F (1984) Treatment of hypercalciuria. N Engl J Med 311: 116–118
Wilson DM (1990) Clinical and laboratory evaluation of renal stone patients. Endocrinol Metab Clin North Am 19:773–803
Abrams SA, Yergey AL, Heaney RP (1994) Relationship between balance and dual tracer isotopic measurements of calcium absorption and excretion. J Clin Endocrinol Metab 79:965–969
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Welch, T.R., Abrams, S.A., Shoemaker, L. et al. Precise determination of the absorptive component of urinary calcium excretion using stable isotopes. Pediatr Nephrol 9, 295–297 (1995). https://doi.org/10.1007/BF02254187
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02254187