Abstract
Repeated subsampling or a hierarchical design of experiments combined with an analysis of variance (ANOVA) is demonstrated to be a useful tool in the determination of uncertainty components in amount-of-substance measurements. With the reference material of human serum as investigated here for total cholesterol, besides several in-laboratory sources of uncertainty, a vial-to-vial effect which can be regarded as an off-laboratory source was found to be significant. This knowledge might be essential when the material is used for calibration and for the self-assessment of a laboratory.
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Received: 29 October 1997 · Accepted: 26 November 1997
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Henrion, A. In- and off-laboratory sources of uncertainty in the use of a serum standard reference material as a means of accuracy control in cholesterol determination. Accred Qual Assur 3, 127–130 (1998). https://doi.org/10.1007/s007690050204
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DOI: https://doi.org/10.1007/s007690050204