N,N′,N″,N‴
-pentaacetic acid) bearing different substituents for binding to human serum albumin (HSA) are compared. In spite of the structural differences of the recognition synthon and of the residual electric charge, the two chelates display an analogous binding affinity for the serum protein. Upon formation of the adducts with HSA, the exchange rates of the coordinated water appear slowed down by an amount corresponding to ca. 50% of the rates found for the free complexes. The relaxivity of [Gd(BOM)3DTPA (H2O)]2 − is significantly higher than that of MS-325 either in the free complex or in the macromolecular adduct. Finally, the effect of pH on the stability of the HSA adducts and on the values of their relaxivities has been investigated.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 11 June 1999 / Accepted: 15 September 1999
Rights and permissions
About this article
Cite this article
Aime, S., Chiaussa, M., Digilio, G. et al. Contrast agents for magnetic resonance angiographic applications: 1H and 17O NMR relaxometric investigations on two gadolinium(III) DTPA-like chelates endowed with high binding affinity to human serum albumin. JBIC 4, 766–774 (1999). https://doi.org/10.1007/s007750050349
Issue Date:
DOI: https://doi.org/10.1007/s007750050349