Abstract
In a prospective study to determine the prevalence of parvovirus B19 in adult patients positive for the human immunodeficiency virus, a series of 55 consecutively presenting patients was tested for antibodies to parvovirus B19 and parvovirus B19 DNA. Specific IgG antibodies were detected in 96% of cases; specific IgM antibodies were present in 10%. Viral DNA was not detected in any of the sera analysed by polymerase chain reaction. Anemia could not be correlated with the presence of either IgG or IgM antibodies to parvovirus B19. Thus, no evidence of acute or chronic parvovirus B19 infection was found in the 55 patients. These findings suggest that active parvovirus B19 infection is uncommon in HIV-infected patients.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Cossart YE, Field AM, Cant B, Widdows D: Parvovirus-like particles in human sera. Lancet 1975, i: 72–73.
Kurtzman GJ, Ozawa K, Cohen B, Hanson G, Oseas R, Young NS: Chronic bone marrow failure due to persistent B19 parvovirus infection. New England Journal of Medicine 1987, 317: 287–294.
Kurtzman GJ, Frickhofen N, Kimball J, Jenkins DW, Nienhuis AW, Young NS: Pure red-cell aplasia of 10 years' duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy. New England Journal of Medicine 1989, 321: 519–523.
Frickhofen N, Abkowitz JL, Safford M, Berry JM, Antunez-de-Mayolo J, Astrow A, Cohen R, Halperin I, King L, Mintzer D, Cohen B, Young NS: Persistent B19 parvovirus infection in patients infected with human immunodeficiency virus type 1: a treatable cause of anemia in AIDS. Annals of Internal Medicine 1990, 113: 926–933.
Gray JJ, Cohen BJ, Desselberger U: Detection of human parvovirus specific IgM and IgG antibodies using a recombinant viral VP1 antigen expressed in insect cells and estimation of time of infection by testing for antibody avidity. Journal of Virological Methods 1993, 44: 11–24.
Musiani M, Zerbini M, Gentilomi G, Rodorigo G, De Rosa V, Gibellini D, Venturoli S, Gallinella G: Persistent B19 parvovirus infections in haemophilic HIV-1 infected patients. Journal of Medical Virology 1995, 46: 103–106.
Zon Li, Groopman JE: Hematologic manifestations of the human immunodeficiency virus. Seminars in Hematology 1988, 25:208–218.
Anderson MJ, Kidd IM, Jones BS, Pattison JR, Grieco MH, Lange M, Buimovici-Klein E, Cooper LZ: Parvovirus infection and the acquired immunodeficiency syndrome. Annals of Internal Medicine 1985, 102: 275.
Naides SJ, Howard EJ, Swack NS, True CA, Stapleton JT: Parvovirus B19 infection in human immunodeficiency virus type 1-infected persons failing or intolerant to zidovudine therapy. Journal of Infectious Diseases 1993, 168: 101–105.
Morinet F, D'auriol L, Traschin JD, Galibert F: Expression of the human parvovirus B19 protein fused to protein A inEscherichia coli: recognition by IgM and IgG antibodies in human sera. Journal of General Virology 1989, 70: 3091–3097.
Morinet F, Courouce AM, Galibert F, Perol Y: The use of labeled fusion protein for detection of B19 parvovirus IgM antibodies by an immunocapture test. Journal of Virological Methods 1991, 32: 21–30.
Arakelov S, Gorny MK, Williams C, Riggin CH, Brady F; Collett MS, Zolla-Pazner S: Generation of neutralizing anti-B19 parvovirus human monoclonal antibodies from patients infected with human immunodeficiency virus. Journal of Infectious Diseases 1993, 168: 580–585.
Chernak E, Dubin G, Henry D, Naides SJ, Hodinka RL, Roy MacGregor RR, Friedman HM: Infection due to parvovirus B19 in patients infected with human immunodeficiency virus. Clinical Infectious Diseases 1995, 20: 170–173.
Bremner JAG, Cohen BJ: Parvovirus B19 as a cause of anemia in human immunodeficiency virus-infected patients. Journal of Infectious Diseases 1994, 169: 938–940.
Torok TJ: Parvovirus B19 and human disease. Advances in Internal Medicine 1992, 37: 431–455.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Raguin, G., Leruez-Ville, M., Gregoire, V. et al. Low prevalence of active parvovirus B19 infection in HIV-infected patients. Eur. J. Clin. Microbiol. Infect. Dis. 16, 760–762 (1997). https://doi.org/10.1007/BF01709261
Issue Date:
DOI: https://doi.org/10.1007/BF01709261