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Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging

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Abstract

Diffusion-weighted and susceptibility-contrast-enhanced magnetic resonance imaging were used to monitor the development of focal ischemia in cat brain. Diffusion-sensitized imaging was used to assess early ischemic tissue damage which was confirmed for the latest time point (∼12 h) with postmortem histological analysis.T*2-sensitized FLASH was used to measure the first passage of a bolus of FeO particles. Gamma function fitting of ΔR*2-time curves resulted in 2D maps of relative hemodynamic parameters, including cerebral blood volume and flow. The present data provide indications for cerebral blood flow thresholds for acute as well as for delayed ischemic tissue damage.

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Authors and Affiliations

  1. Department of Neurosurgery, Utrecht University, NL-3584 CJ, Utrecht, The Netherlands

    H. B. Verheul, R. M. Dijkhuizen, J. -W. Berkelbach van der Sprenkel & C. A. F. Tulleken

  2. Bijvoet Center, Utrecht University, NL-3584 CJ, Utrecht, The Netherlands

    K. S. Tamminga, R. M. Dijkhuizen & K. Nicolay

Authors
  1. H. B. Verheul
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  2. K. S. Tamminga
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  3. R. M. Dijkhuizen
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  4. J. -W. Berkelbach van der Sprenkel
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  5. C. A. F. Tulleken
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  6. K. Nicolay
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Verheul, H.B., Tamminga, K.S., Dijkhuizen, R.M. et al. Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging. MAGMA 2, 367–370 (1994). https://doi.org/10.1007/BF01705274

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