Abstract
Chemical shift imaging (CSI) was applied to measure natural abundance proton-decoupled13C-NMR spectra of the human liver. Large surface coils were designed for13C spectra acquisition (16-cm-diameter circular coil) as well as for proton imaging and decoupling (21×20-cm butterfly coil). Such sizes allowed deep observations of the abdomen. A space matrix of 8×4 voxels (4×8 cm each) was defined using 32 phase-encoding steps. Magnetic field gradients were adjusted on multicompartment phantoms to limit contamination between voxels. Spectral maps containing {1H}-13C spectra of liver from healthy volunteers with an acceptable signal-to-noise ratio were recorded within 20 min. Liver spectra exhibited well-defined resonances corresponding to fatty acyl chains, carbonyl groups, and sugars. The (C-l)-glycogen resonance was also detected under such conditions. Such a technique would be of interest in the development of metabolic investigations on the human liverin vivo.
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Thiaudière, E., Biran, M., Delalande, C. et al. In vivo 13C chemical shift imaging of the human liver. MAGMA 2, 425–428 (1994). https://doi.org/10.1007/BF01705289
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DOI: https://doi.org/10.1007/BF01705289