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UV-B and early cortical and nuclear changes in the human lens

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Abstract

Experimental studies in mice and rats have shown that UV (B) irradiation leads to specific lens changes, viz. yellowing of the nucleus and a multilayered epithelium in the anterior pole with disrupted cortical fibres underneath. Biomicroscopic and ultrastructural studies on ageing human lenses revealed yellowing of the lens nucleus and locally ruptured membranes and small opcities in the equatorial cortex. No changes in the anterior pole were ever observed. This discrepancy between the human and animal lens, contraindicating UV as an important risk factor for human cataract, is discussed and may be due to several factors: (1) a difference between the high level acute and low level chronic irradiation; (2) species differences: nocturnal animals may be unable to cope with bright light exposure; (3) differences in scavenger and other defense mechanisms between humans and animals.

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Authors and Affiliations

  1. Department of Morphology, The Netherlands Ophthalmic Research Institute, P.O. Box 12141, 1100 AC, Amsterdam, The Netherlands

    Gijs F. J. M. Vrensen

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  1. Gijs F. J. M. Vrensen
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Vrensen, G.F.J.M. UV-B and early cortical and nuclear changes in the human lens. Doc Ophthalmol 88, 255–261 (1995). https://doi.org/10.1007/BF01203679

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