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Thrombosis, recurrent abortions and intrauterine foetal death in a patient with lupus anticoagulant

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Summary

The authors describe a case report of a patient suffering from thrombosis and recurrent abortions. Routine coagulation screening was abnormal and investigation showed the presence of a circulating anticoagulant. High titres of anticardiolipin antibodies were demonstrated. Antinuclear antibodies were slightly positive and antinative DNA antibodies were present. Lupus anticoagulant activity and anticardiolipin antibodies seem to be strong markers of a thrombotic tendency.

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References

  1. Conley, C.L., Hartmann, R.C. A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus. J Clin Invest 1952, 31, 621.

    Google Scholar 

  2. Feinstein, D.I., Rappaport, S.I. Acquired inhibitors of blood coagulation. Prog Hemost Thromb 1972, 1, 75.

    PubMed  CAS  Google Scholar 

  3. Laurell, A.B., Nilsson, I.M. Hypergammaglobulinemia, circulating anticoagulant and biologic false positive Wasserman reaction. J Lab Clin Med 1957, 49, 694.

    PubMed  CAS  Google Scholar 

  4. Boxer, M., Ellman, L., Carvalho, A. The lupus anticoagulant. Arthritis Rheum 1976, 19, 1244.

    PubMed  CAS  Google Scholar 

  5. Schleider, M.A., Nachman, R.L., Jaffe, E.A., Coleman, M. A clinical study of the lupus anticoagulant. Blood 1976, 48, 499.

    PubMed  CAS  Google Scholar 

  6. Much, J.R., Herbst, K.D., Rappaport, S.I. Thrombosis in patients with the lupus anticoagulant. Ann Intern Med 1980, 92, 156.

    PubMed  Google Scholar 

  7. Albert, J., Ekoe, J.M., Cunningham, M., Humair, L. Circulating anticoagulant in CREST syndrome. Br J Rheumatol 1984, 23, 20.

    PubMed  CAS  Google Scholar 

  8. Exner, T., Rickard, K.A., Kronenberg, H. A sensitive test demonstrating lupus anticoagulant and its behavioural patterns. Br J Haematol 1978, 40, 143.

    PubMed  CAS  Google Scholar 

  9. Carreras, L.O., Vermylen, J.G. Lupus anticoagulant and thrombosis: Possible role of inhibition of prostacyclin formation. Thromb Haemost 1982, 48, 38.

    PubMed  CAS  Google Scholar 

  10. Firkin, B.G., Howard, M.A., Radford, N. Possible relationship between lupus inhibitor and recurrent abortion in young women. Lancet 1980, ii, 366.

    Article  Google Scholar 

  11. Lechner, K. Acquired inhibitor in nonhaemophilic patients. Haemostasis 1974, 3, 65.

    PubMed  CAS  Google Scholar 

  12. Carreras, L.O., Defreyn, G., Machin, S.J., et al. Arterial thrombosis, intrauterine death and “lupus” anticoagulant: Detection of immunoglobulin interfering with prostacyclin formation. Lancet 1981, 1, 244.

    Article  PubMed  CAS  Google Scholar 

  13. Sanfelippo, M.J., Drayana, C.J. Prekallikrein inhibition associated with the lupus anticoagulant: A mechanism of thrombosis. Am J Clin Pathol 1982, 77, 275.

    PubMed  CAS  Google Scholar 

  14. Nilsson, I.M., Astedt, B., Hender, U., et al. Intrauterine death and circulating anticoagulant. Acta Med Scand 1975, 197, 153.

    Article  PubMed  CAS  Google Scholar 

  15. Carreras, L.O., Vermylen, J., Spitz, B., et al. Lupus anticoagulant and inhibition of prostacyclin formation in patient with repeated abortion, intrauterine growth retardation and intrauterine death. Br J Obstet Gynaecol 1981, 88, 890.

    PubMed  CAS  Google Scholar 

  16. Remuzzi, G., Misiani, R., Muratori, D., et al. Prostacyclin and human fetal circulation. Prostaglandins 1981, 18, 341.

    Google Scholar 

  17. Lubbe, W.F., Butler, W.S., Palmer, S.J., et al. Fetal survival after prednisone suppression of maternal lupus anticoagulant. Lancet 1983, 1, 1361.

    Article  PubMed  CAS  Google Scholar 

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Altomonte, L., Zoli, A., Accili, D. et al. Thrombosis, recurrent abortions and intrauterine foetal death in a patient with lupus anticoagulant. Clin Rheumatol 4, 455–457 (1985). https://doi.org/10.1007/BF02031900

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  • DOI: https://doi.org/10.1007/BF02031900

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