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Single photon emission computed tomography with99mTc HM-PAO in the study of focal epilepsy

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Abstract

We used99mTc HM-PAO SPECT to study 50 patients with partial epilepsy: 47 interically and 3 during a seizure. All 3 patients studied during a seizure presented an area of increased tracer uptake. Of those in whom recordings were taken during seizure-free intervals 35 (74%) showed perfusion asymmetries: 27 (57%) with decreased and 8 (17%) with increased uptake. We discuss the findings and compare them with those of similar studies using SPECT and positron emission tomography.

Sommario

Sono stati studiati mediante SPECT con99mTc HM-PAO 50 pazienti affetti da epilessia parziale, 47 in fase intercritica e 3 durante la crisi. Tutti i pazienti registrati in fase critica hanno dimostrato un focolaio di iperfissazione del tracciante. Tra quelli registrati in fase intercritica 35 (74%) hanno evidenziato asimmetrie di perfusione di cui 27 (57%) ipofissanti ed 8 (17%) iperfissanti. I risultati sono discussi e confrontati con quelli di analoghi lavori condotti mediante tomoscintigrafia e tomografia a positroni.

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Authors and Affiliations

  1. Servizio di Medicina Nucleare, Ospedale S. Croce, Cuneo

    Camuzzini G. F., Papaleo A., Acchiardi F. & Perno G.

  2. Divisione Neurologia, Ospedale “S. Croce”, Via M. Coppino 26, 12100, Cuneo

    Grasso E., Ambrogio L., Cognazzo A., Gerbino-Promis P. C. & Zagnoni P.

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  1. Grasso E.
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  2. Ambrogio L.
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  3. Cognazzo A.
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  4. Gerbino-Promis P. C.
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  5. Zagnoni P.
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  6. Camuzzini G. F.
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  7. Papaleo A.
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  8. Acchiardi F.
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  9. Perno G.
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Grasso, E., Ambrogio, L., Cognazzo, A. et al. Single photon emission computed tomography with99mTc HM-PAO in the study of focal epilepsy. Ital J Neuro Sci 10, 175–179 (1989). https://doi.org/10.1007/BF02333615

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