Skip to main content
SpringerLink
Log in

Bile duct hyperplasia and transient liver parenchymal cell alteration by methylisocyanate

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Arora Usha, Vijayaraghavan R (1989) Effect of sublethal exposure to methylisocyanate on testicular histomorphology in mice. Ind J Expt Biol 27:247–249

    Google Scholar 

  • Bhattacharya BK, Sharma SK, Jaiswal DK (1988) In Vivo binding of (1-c14) methylisocyanate to various tissue proteins. Biochem Pharmacol 37:2489–2490

    Google Scholar 

  • Boorman GA, Brown R, Gupta BN, Uraih LC, Bucher JR (1987) Pathological changes following acute methylisocyanate inhalation and recovery in B6C3F1 mice. Toxicol Appl Pharmacol 87:446–456

    Google Scholar 

  • Bucher JR, Gupta BN, Adkins Jr B, Thompson M, Jameson CW, Thigpen JE, Schwetz BA (1987) Toxicity of inhaled methylisocyanate in F344/N rats and B6C3F1 mice. 1 Acute exposure and recovery studies. Environ Hlth Perspect 72:53–61

    Google Scholar 

  • Chowdhury AR, Rastogy VK, Arora Usha, Saxena Chhaya (1985) Biochemical and morphological alteration of adrenal under the exposure of orthochlorobenzylidene malononitrile. Mikroskopie 42:151–156

    Google Scholar 

  • Cohen S, Oppenheimer E (1977) Biological formation and reactions of cyanates. In: The chemistry of cyanates and their thioderivatives. Patai S.(ed). John Wiley and Sons. New York

    Google Scholar 

  • Crofton PM, Elton RA, Smith AF (1979) High molecular weight alkaline phosphatase in clnical study. Clin Chim Acta 98:263–275

    Google Scholar 

  • Culling CFA (1974) Handbook of histopathological and histochemical technique 3rd ed. Butterworth & Co Ltd, London

    Google Scholar 

  • Fowler EH, Dodd DE (1986) Acute inhalation studies with methylisocyanate vapour. Part II Respiratory tract changes in guinea pigs, rats and mice. Fund Appl Toxicol 6:756–771

    Google Scholar 

  • Goldfarb S, Singer EJ, Popper H (1962) Experimental cholangitis due to alpha naphthyl isothiocyanate (ANIT). Amer J Pathol 40:658–698

    Google Scholar 

  • Goldfarb S, Singer EJ, Popper H (1963) Biliary ductules and bile secretion. J Lab Clin Med 62:608–615

    Google Scholar 

  • Husain K, Matin MA (1987) Role of adrenals in the production of hyperglycaemia and changes in hepatic carbohydrate metabolism in diazinon treated rats. Adv Biosci 61:101–105

    Google Scholar 

  • Hyde TA, Draisy TF (1974) Principals of chemical pathology. Butterworths and Co Ltd, London

    Google Scholar 

  • Jeevarathinam K, Selvamurthy W, Ray US, Mukhopadhyay S, Thakur L (1988) Acute toxicity of methylisocyanate, administered subcutaneously in rabbits, changes in physiological,clino chemical parameters. Toxicology 51:223–240

    Google Scholar 

  • Jubb KVF, Kennedy PC, (1970) Pathology of domestic animals. Second ed. Academic Press, New York, San Francisco, London

    Google Scholar 

  • Lopez M, Mazzanti L (1955) Experimental investigation on alpha- naphthylisocyanate as a hyperplastic agentes of the biliary ducts in rats. J Pathol Bacteriol 69:243–250

    Google Scholar 

  • Lowry OH, Rosebrough NJ, Farr AL, Randall (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265–275

    CAS  PubMed  Google Scholar 

  • Nelson N (1944) A photometric adaptation of Somogyi method for the determination of glucose. J Biol Chem 153:375–380

    Google Scholar 

  • Rappaport AM (1969) Anatomical consideration in Leon Schiff ed. “Disease of the liver” 3rd ed. J Lippincott Co Philadelphia 1–49

    Google Scholar 

  • Reitman S, Frankel S (1954) A colorimetric method for determination of serum oxaloacetic and glutamate. Amer J Clin Pathol 28:56–63

    Google Scholar 

  • Slatter JG, Rashed MS, Pearson PG, Han DH, Baillie TA (1991) Biotransformation of methylisocyanate in the rat. Evidence for glutathion conjugation as a major pathway of metabolism and implication for isocyanate mediated toxicities. Chem Res Toxicol 4:157–161

    Google Scholar 

  • Varma DR, Ferguson JS, Alarie Y (1987) Reproductive toxicity of methylisocyanate in mice. J Toxicol Environ Hlth 21:265–275

    Google Scholar 

  • Vijayaraghavan R, Kaushik MP (1987) Acute toxicity of methylisocyanate and ineffectiveness of the sodiumthiosulphate preventing its toxicity. Ind J Exp Biol 25:531–534

    Google Scholar 

  • Wooton IDP, Freeman H (1982) Microanalysis in medical biochemistry, 6th ed. Churchill Ltd, London

    Google Scholar 

  • Zajicek G, Oren R, Weinreb M Jr (1985) The streaming liver. Liver 5:293–300

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Pharmacology and Toxicology, Defence Research & Development Establishment, 474 002, Gwalior, India

    Usha Arora, R. Vijayaraghavan & K. Sugendran

  2. School of Studies in Zoology Jiwaji University, Gwalior, India

    R. Mathur

Authors
  1. Usha Arora
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Vijayaraghavan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Sugendran
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Mathur
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Arora, U., Vijayaraghavan, R., Sugendran, K. et al. Bile duct hyperplasia and transient liver parenchymal cell alteration by methylisocyanate. Bull. Environ. Contam. Toxicol. 51, 211–218 (1993). https://doi.org/10.1007/BF00198883

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00198883

Keywords

Search

Navigation