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Increased 1,25-dihydroxyvitamin D3 synthesis in rats fed a high-phosphorus diet

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Summary

Rats fed vitamin D-deficient diets containing 0.6% Ca and 0.3%, 0.6%, 1.2%, or 1.8% P exhibited progressive increments of hypocalcemia and hyperphosphatemia. In vitro assay of 25-hydroxyvitamin D3-1-α-hydroxylase (1-α-hydroxylase) activity in isolated kidney cortical mitochondria showed that hyperphosphatemia in the presence of hypocalcemia was associated with an increase in enzyme activity. The results indicate that the stimulation of 1-α-hydroxylase associated with depressed plasma Ca in rats fed a high-P diet overrides any inhibition of the enzyme that may be caused by excess plasma phosphate.

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Authors and Affiliations

  1. Department of Nutrition, College of Biological Science, University of Guelph, N1G 2W1, Guelph, Ontario, Canada

    G. M. Siu & H. H. Draper

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  1. G. M. Siu
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  2. H. H. Draper
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Siu, G.M., Draper, H.H. Increased 1,25-dihydroxyvitamin D3 synthesis in rats fed a high-phosphorus diet. Calcif Tissue Int 33, 667–672 (1981). https://doi.org/10.1007/BF02409506

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