Skip to main content
SpringerLink
Log in

Effect of 1,25-dihydroxyvitamin D3 on osteopenia induced by prednisolone in adult rats

  • Laboratory Investigations
  • Published:
Calcified Tissue International Aims and scope Submit manuscript

Summary

Adult male rats were fed a diet containing 0.15% calcium, 0.3% phosphorus, and either 100, 50, or 20 mg of prednisolone per kg of diet. All these levels of prednisolone led to osteopenia, decreased intestinal absorption of calcium, slightly lower serum calcium and phosphorus, and a decreased level of serum 1,25-dihydroxyvitamin D3. Exogenous parenteral 1,25-dihydroxyvitamin D3 corrected steroid-induced changes in serum calcium and phosphorus, but could not completely correct the low intestinal calcium transport; nor did it prevent the development of osteopenia. The prednisolone-induced osteopenia seems at least in part to be caused by impaired intestinal calcium transport. The impaired calcium transport may be the result of low levels of 1,25-dihydroxyvitamin D3 and a direct effect of presnisolone on the intestine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chen PS Jr, Toribara TY, Warner H (1956) Microdetermination of phosphorus. Anal Chem 28:1756–1758

    Article  CAS  Google Scholar 

  2. Favus MJ, Walling MW, Kimberg DV (1973) Effects of 1,25-dihydroxycholecalciferol on intestinal calcium transport in cortisone-treated rats. J Clin Invest 52:1680–1685

    CAS  PubMed  Google Scholar 

  3. Gallagher JC, Aaron J, Horsman A, Wilkinson R, Nordin BEC (1973) Corticosteroid osteoporosis. J Clin Endocrinol Metab 2:355–368

    Article  CAS  Google Scholar 

  4. Kimberg DV, Bacry RD, Gershon E, Graudusius RT (1971) Effect of cortisone treatment on the active transport of calcium by the small intestine. J Clin Invest 50:1309–1321

    CAS  PubMed  Google Scholar 

  5. Klein RG, Arnaud SB, Gallagher JC, DeLuca HF, Riggs BL (1977) Intestinal calcium absorption in exogenous hypercortisonism. J Clin Invest 60:253–259

    Article  CAS  PubMed  Google Scholar 

  6. Lindgren U, Lindholm S, Sarby B (1978) Short-term effects of 1 alpha-hydroxyvitamin D3 in patients on corticosteroid treatment and in patients with senile osteoporosis. Acta Med Scand 204:89–92

    Article  CAS  PubMed  Google Scholar 

  7. Martin DL, DeLuca HF (1969) Influence of sodium on calcium transport by the rat small intestine. Am J Physiol 261:135–139

    Google Scholar 

  8. Shepard RM, Horst RL, Hamstra AJ, DeLuca HF (1979) Determination of vitamin D and its metabolites in plasma from normal and anephric man. Biochem J 182:55–69

    CAS  PubMed  Google Scholar 

  9. Storey E (1960) Bone changes associated with cortisone administration in the rat. Br J Exp Pathol 41:207–213

    CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. J. U. Lindgren

    Present address: Department of Orthopedic Surgery, 14186 Huddinge Hospital, Stockholm, Sweden

Authors and Affiliations

  1. Department of Biochemistry, College of Agricultural and Life Sciences, USA

    J. U. Lindgren, C. R. Merchant & H. F. DeLuca

  2. Department of Orthopedic Surgery, School of Medicine, University of Wisconsin-Madison, 53706, Madison, Wisconsin, USA

    J. U. Lindgren, C. R. Merchant & H. F. DeLuca

Authors
  1. J. U. Lindgren
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. R. Merchant
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. F. DeLuca
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

No reprints of this article will be available from the authors.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lindgren, J.U., Merchant, C.R. & DeLuca, H.F. Effect of 1,25-dihydroxyvitamin D3 on osteopenia induced by prednisolone in adult rats. Calcif Tissue Int 34, 253–257 (1982). https://doi.org/10.1007/BF02411246

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02411246

Key words

Search

Navigation