Summary
This study was done to determine if steroid compounds will stimulate the urinary bladder of the toad to increase its capacity to acidify the urine and excrete NH +4 , Aldosterone, 17β-estradiol, dexamethasone, pregnenolone, and cholesterol were tested on the bladder. All compounds tested were found to stimulate the rate of acidification by the bladder, above that of a paired control hemibladder. In contrast, only the steroids aldosterone and 17β-estradiol were found to stimulate NH +4 excretion in the bladder. Cycloheximide was found to block the action of aldosterone on the NH +4 excretion, but did not have a significant effect on the stimulation of acidification by aldosterone. We conclude that steroids stimulate H+ and NH +4 excretion in the toad urinary bladder. In addition, the NH +4 excretory system seems to be more specific to this effect than is the H+ excretory system.
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Frazier, L.W., Zachariah, N.Y. Action of steroids on H+ and NH +4 excretion in the toad urinary bladder. J. Membrain Biol. 49, 297–308 (1979). https://doi.org/10.1007/BF01868988
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DOI: https://doi.org/10.1007/BF01868988