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Inhibitors of the dicarboxylate and tricarboxylate transporting systems of rat liver mitochondria

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Summary

A large number of compounds were tested for their effectiveness as inhibitors of the tricarboxylate and dicarboxylate transporting systems of rat liver mitochondria as monitored by citrate/[14C] citrate exchange and phosphate/[14C]l-malate exchange, respectively. The influence of inhibitor structure on inhibitory potency is discussed for each transporting system and deductions made concerning the nature of the binding sites of these carrier systems.

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References

  1. Chappell, J. B., Haarhoff, K. N. 1966. The penetration of the mitochondrial membrane by anions and cations.In: Biochemistry of Mitochondria E. C. Slater, Z. Kaniuga and L. Wojtcak, editors. p. 75. Academic Press Inc., New York, and Polish Scientific Publishers, Warsaw.

    Google Scholar 

  2. Chappell, J. B., Robinson, B. H. 1968. Penetration of the mitochondrial membrane by tricarboxylic acid anions.Biochem. Soc. Symp. 27:123.

    PubMed  Google Scholar 

  3. Ferguson, S. M. F., Williams, G. R. 1966. The effect of malate and other dicarboxylic acids on mitochondrial isocitrate metabolism.J. Biol. Chem. 241:3969.

    Google Scholar 

  4. Prelog, V., Schneider, R. 1949. Untersuchungen über Organextrakte. Über die Lage der zweiten Carbonyl-Gruppe im Diketon D (Oxo-cis-tetrahydro-jonen) aus dem Harn trächtiger Stuten.Helv. Chim. Acta 32:1632.

    Google Scholar 

  5. Quagliariello, E., Palmieri, F., Prezioso, G., Klingenberg, M. 1969. Kinetics of succinate uptake by rat-liver mitochondria.F.E.B.S. 4:251.

    Google Scholar 

  6. Robinson, B. H., Chappell, J. B. 1967. The inhibition of malate, tricarboxylate and oxoglutarate entry into mitochondria by 2-n-butylmalonate.Biochem. Biophys. Res. Commun. 28:249.

    PubMed  Google Scholar 

  7. Robinson, B. H., Chappell, J. B. 1970. The kinetics of tricarboxylate anion oxidation by rat liver mitochondria in relation to the availability ofl-malate.Biochim. Biophys. Acta 205:300.

    PubMed  Google Scholar 

  8. Robinson, B. H., Williams, G. R. 1969. The effect on mitochondrial oxidations of inhibitors of the dicarboxylate anion transporting system.F.E.B.S. 5:301.

    Google Scholar 

  9. Robinson, B. H., Williams G. R. 1970. The sensitivity of dicarboxylate anion exchange reactions to transport inhibitors in rat-liver mitochondria.Biochim. Biophys. Acta 216:63.

    PubMed  Google Scholar 

  10. Robinson, B. H., Williams, G. R., Halperin, M. L., Leznoff, C. C. 1970. The effects of 2-ethylcitrate and tricarballylate on citrate transport in rat liver mitochondria and fatty acid synthesis in rat white adipose tissue.Europ. J. Biochem. 15:263.

    PubMed  Google Scholar 

  11. Robinson, B. H., Williams, G. R., Halperin, M. L., Leznoff, C. C. 1971. The sensitivity of the exchange reactions of tricarboxylate, 2-oxoglutarate and dicarboxylate transporting systems of rat liver mitochondria to inhibition of 2-pentylmalonatep-iodobenzylmalonate and benzene 1,2,3-tricarboxylate.Europ. J. Biochem. 20:65.

    PubMed  Google Scholar 

  12. Robinson, B. H., Williams, G. R., Halperin, M. L., Leznoff, C. C. 1971. Factors affecting the kinetics and equilibrium of exchange reactions of the citrate-transporting system of rat liver mitochondria.J. Biol. Chem. 246:5280.

    PubMed  Google Scholar 

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Author notes

  1. B. H. Robinson

    Present address: Department of Zoology, University of Sheffield, S102 TN, England

Authors and Affiliations

  1. Departments of Biochemistry and Medicine, University of Toronto, Toronto 5, Ontario, Canada

    B. H. Robinson, G. R. Williams, M. L. Halperin & C. C. Leznoff

  2. Department of Chemistry, York University, Downsview, Ontario, Canada

    B. H. Robinson, G. R. Williams, M. L. Halperin & C. C. Leznoff

Authors
  1. B. H. Robinson
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  2. G. R. Williams
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  3. M. L. Halperin
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  4. C. C. Leznoff
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Robinson, B.H., Williams, G.R., Halperin, M.L. et al. Inhibitors of the dicarboxylate and tricarboxylate transporting systems of rat liver mitochondria. J. Membrain Biol. 7, 391–401 (1972). https://doi.org/10.1007/BF01867928

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  • DOI: https://doi.org/10.1007/BF01867928

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