Summary
Successive measurements of cardiac myosin light chain I (MLC), creatine kinase isoenzyme MB (CKMB), and the titer of antimyosin antibody (AMA) were performed prospectively in 19 patients following open heart surgery. Seven of these patients showed the postpericardiotomy syndrome (PPS). No differences in serum concentrations of MLC or CKMB were observed between the patients with and without PPS, and all patients in both groups had abnormal MLC values after surgery. However, only patients with PPS had significantly elevated AMA titers. The maximum AMA titer was significantly correlated with the severity of the effusion. These data suggest that PPS is unrelated to the severity of myocardial injury during operation. Furthermore, the AMA titer may be useful as one of the indicators for determining the patient's clinical condition.
Similar content being viewed by others
References
Behrman RE, Vaughan VC (1987) Disease of the pericardium. In:Nelson textbook of pediatrics. WB Saunders, Philadelphia, pp 1024–1026
Béland MJ, Paquet M, Gibbons JE, Tchervenkov CI, Dobell ARC (1990) Pericardial effusion after cardiac surgery in children and effects of aspirin for prevention.Am J Cardiol 65:1238–1241
Clapp SK, Garson A, Gutgesell HP, Cooley DA, McNamara DG (1980) Postoperative pericardial effusion and its relation to postpericardiotomy syndrome.Pediatrics 66:585–588
De Scheerder I, De Buyzere M, Robbrecht J, et al. (1986) Postoperative immunological response against contractile proteins after coronary bypass surgery.Br Heart J 56:440–444
De Scheerder I, Vandekerckhove J, Robbrecht J, et al. (1985) Post-cardiac injury syndrome and an increased humoral immune response against the major contractile proteins (actin and myosin).Am J Cardiol 56:631–633
De Scheerder I, Wulfrank D, Vanrenterghem L, et al. (1984) Association of antiheart antibodies and circulating immune complexes in the post-pericardiotomy syndrome.Clin Exp Immunol 57:423–428
Engle MA, Gay WA Jr, Kaminsky ME, Zabriskie JB, Senterfit LB (1978) The postpericardiotomy syndrome then and now.Curr Probl Cardiol 3:1–40
Engle MA, Zabriskie JB, Senterfit LB, Gay WA, O'Loughlin JE, Ehlers KH (1980) Viral illness and the postpericardiotomy syndrome: a prospective study in children.Circulation 6:1151–1158
Neu N, Ploier B, Nfner C (1990) Cardiac myosin-induced myocarditis: heart autoantibodies are not involved in the induction of the disease. J Immunol 145:4094–4100
Neu N, Rose NR, Beisel KW, Herskowitz A, Gurri-Glass G, Craig SW (1987) Cardiac myosin induces myocarditis in genetically predisposed mice.J Immunol 139:3630–3636
Nomura Y, Yoshinaga M, Noda T, et al. (1991) Changes in titer of the anti-myosin antibody in a patient with post-pericardiotomy syndrome [English abstract].Acta Cardiol Paediatr Jpn 7:320–324
Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proc Natl Acad Sci USA 76:4350–4354
Voller A, Bidwell D (1986) Enzyme-linked immunosorbent assay. In: Rose NR, Friedman H, Fahey JL (eds)Manual of clinical laboratory immunology. American Society for Microbiology, Washington, DC, pp 99–109
Weitzman LB, Tinker WP, Konzon I, Cohen ML, Glassman E, Spencer FC (1984) The incidence and natural history of pericardial effusion after cardiac surgery: an echocardiographic study.Circulation 69:506–511
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nomura, Y., Yoshinaga, M., Haraguchi, T. et al. Relationship between the degree of injury at operation and the change in antimyosin antibody titer in the postpericardiotomy syndrome. Pediatr Cardiol 15, 116–120 (1994). https://doi.org/10.1007/BF00796322
Issue Date:
DOI: https://doi.org/10.1007/BF00796322