Skip to main content
Log in

Angiomyolipoma of the liver: significance of CT and MR dynamic study

  • Published:
Abdominal Imaging Aims and scope Submit manuscript

Abstract

Angiomyolipoma is a benign mesenchymal tumor that has been reported frequently in the kidney but rarely in the liver. In the present study, we present four cases of hepatic angiomyolipoma with different radiologic appearances, discuss differential diagnosis, and review previously reported cases. One of our cases was followed for 8 years. Computed tomography (plain, enhanced, and dynamic study), magnetic resonance imaging (T1-weighted spin echo, T2-weighted spin echo, and dynamic study), ultrasonography, and angiography were performed in all cases. Although different radiologic appearances were observed in the tumors, based on different proportions of fat, blood vessels, and muscle, three cases were diagnosed as angiomyolipoma. In one case, it was quite difficult to make radiologic diagnosis; hepatocellular carcinoma with fatty metamorphosis in part was most likely suspected, but histopathological examination revealed angiomyolipoma with few fat elements. In the present study, early and prolonged enhancement of the lesion with the special pattern of time density/intensity curve was significant for angiomyolipoma, and we suggest that preoperative radiologic diagnosis of the lesion is possible in most of the cases. However, it can be quite difficult to distinguish angiomyolipoma from some hepatocellular carcinomas with fatty metamorphosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Nanomura A, Mizukami Y, Kadoya M. Angiomyolipoma of the liver: a collective review. J Gastroenterol 1994;29:95–105

    Article  Google Scholar 

  2. Ishak KG. Mesenchymal tumors of the liver. In: Okuda K, Peters RL, eds. Hepatocellular carcinoma. New York: Wiley Medical, 1976:247–307

    Google Scholar 

  3. Bender BL, Yunis EJ. The pathology of the tuberous sclerosis. Pathol Annu 1982;17:339–382

    PubMed  Google Scholar 

  4. Hooper LD, Mergo Ros PR. Multiple hepatorenal angiomyolipomas: diagnosis with fat suppression, gadolinium-enhanced MRI. Abdom Imaging 1994;19:549–551

    Article  CAS  PubMed  Google Scholar 

  5. Keida Y, Miyagi M, Shahana T, et al. A case of hepatic angiomyolipoma [abstract, in Japanese]. Jpn J Gastroenterol 1986;83:290

    Google Scholar 

  6. Nakashima K, Kimura T, Kojima H, et al. A case of hepatic angiomyolipoma [abstract, in Japanese]. Jpn J Gastroenterol 1986;83:290–291

    Google Scholar 

  7. Blumgart RL, Payne M, Rhodes AH. Angiomyolipoma of the liver. Clin Radiol 1987;38:329–330

    Article  CAS  PubMed  Google Scholar 

  8. Miyahara M, Kobayashi M, Tada I, et al. Giant hepatic angiomyolipoma simulating focal nodular hyperplasia. Jpn J Surg 1988;18:346–350

    Article  CAS  PubMed  Google Scholar 

  9. Fobbe F, Hamm B, Schwarting R. Angiomyolipoma of the liver: CT, MR, and ultrasound imaging. J Comput Assist Tomogr 1988;12:658–659

    Article  CAS  PubMed  Google Scholar 

  10. Aoki Y, Hirai K, Sakado S, et al. A case of hepatic angiomyolipoma. Acta Hepatol Jpn 1987;28:966–970

    Article  Google Scholar 

  11. Naito M, Yamamura F, Takahashi K, et al. Hepatic angiomyolipoma: a case report with review of literature. Acta Pathol Jpn 1988;38:799–804

    CAS  PubMed  Google Scholar 

  12. Kristal H, Sperber F. Hepatic angiomyolipoma in a tuberous sclerosis patient. Isr J Med Sci 1989;25:412–414

    CAS  PubMed  Google Scholar 

  13. Robinson J, Grant EG, Haller JO, Cohen HL. Hepatic angiomyolipoma in tuberous sclerosis: report of two cases. J Ultrasound Med 1989;8:575–578

    CAS  PubMed  Google Scholar 

  14. Miyazaki T, Katehana T, Hachi M, et al. A case of hepatic angiomyolipoma [abstract, in Japanese]. Acta Hepatol Jpn} 1990;31:999

    Google Scholar 

  15. Fujiwara S, Okamoto E, Toyosaka A, et al. Two cases of hepatic angiomyolipoma [abstract, in Japanese]. Acta Hepatol Jpn 1990;31:999

    Google Scholar 

  16. Akatsu J, Tanaka H, Unoki H, et al. A case of hepatic angiomyolipoma mimicking a small liver cancer. Jpn J Gastroenterol 1992;89:1305–1309

    CAS  Google Scholar 

  17. Grippon P, Desaint B, Herve de Sigalon JP, et al. Angiomyolipoma du foie: Une decouverteechographique fortuite. Gastroenterol Clin Biol 1985;9:88–89

    CAS  PubMed  Google Scholar 

  18. Schwartz P, Travers P, Hunt DR. Angiomyolipoma of the liver. Aust NZ J Surg 1989;59:969–971

    Article  CAS  Google Scholar 

  19. Tanabe Y, Yoshida K, Shinomiya S, et al. A case of hepatic angiomyolipoma simulting hepatocellular carcinoma on diagnostic imagings due to atypical histological findings. Jpn J Gastroenterol 1991;88:1608–1611

    CAS  Google Scholar 

  20. Tsui WMS, Yuen AKT, Ma KF, Tse CCH. Hepatic angiomyolipoma with a deceptive trabecular pattern and HMB-45 reactivity. Histopathology 1992;21:569–573

    Article  CAS  PubMed  Google Scholar 

  21. Kawarada Y, Mizumoto R. Angiomyolipoma of the liver. Am J Gastroenterol 1983;78:434–439

    CAS  PubMed  Google Scholar 

  22. Takayasu K, Shima Y, Muramatsu Y, et al. Imaging characteristics of large lipoma and angiomyolipoma of the liver: case reports. Cancer 1987;59:916–921

    Article  CAS  PubMed  Google Scholar 

  23. Suga K, Ito S, Itose K, et al. A case of hepatic angiomyolipoma [in Japanese]. Gastroenterol Surg 1988;11:101–104

    Google Scholar 

  24. Yamagiwa K, Higashikuchi T, Yokoi H, et al. Two cases of hepatic angiomyolipoma and hepatic malignant mixed tumor. Acta Hepatol Jpn 1990;31:1000

    Google Scholar 

  25. Ueda Y, Mimura H, Tsumura M, et al. A case of hepatic artery aneurysm with a big hepatic angiomyolipoma. Acta Hepatol Jpn 1984;25:925–930

    Article  Google Scholar 

  26. Itai Y, Ohtomo K, Kokubo T, et al. CT and MR imaging of fatty tumors of the liver. JCAT 1987;11:253–257

    CAS  Google Scholar 

  27. Goodman ZT. Benign tumors of the liver. In: Okuda K, Ishak KG, eds. Neoplasms of the liver. Tokyo: Springer-Verlag, 1987:105–125

    Chapter  Google Scholar 

  28. Karhunen PJ. Hepatic pseudolipoma. J Clin Pathol 1985;38:877–879

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Wheeler DA, Edmondson HA. Coelomic fat ectopia in the liver. Arch Pathol Lab Med 1985;109:783–785

    CAS  PubMed  Google Scholar 

  30. Brawer MK, Austin GE, Lewin KJ. Focal fatty change of the liver: a hitherto poorly recognized entity. Gastroenterology 1980;78:247–252

    CAS  PubMed  Google Scholar 

  31. Quinn SF, Gosink BB. Characteristic sonographic signs of hepatic fatty infiltration. AJR 1985;145:753–755

    Article  CAS  PubMed  Google Scholar 

  32. Yoshikawa J, Matsui O, Takashima T, et al. Fatty metamorphosis in hepatocellular carcinoma: radiologic features in 10 cases. AJR 1988;151:717–720

    Article  CAS  PubMed  Google Scholar 

  33. Fultz PJ, Hampton WR, Skucas J, Sickel JZ. Differential diagnosis of fat-containing lesions with abdominal and pelvic CT. Radiographics 1993;13:1265–1280

    Article  CAS  PubMed  Google Scholar 

  34. Chang JC, Lee YW, Kim HJ. Perioperative diagnosis of angiomyolipoma of the liver. Abdom Imaging 1994;19:546–548

    Article  CAS  PubMed  Google Scholar 

  35. Peh WCG, Ngan H, Fan ST, Ng IOL. Case report: variable imaging appearances of angiomyolipomas of the liver. Br J Radiol 1995;68:540–544

    Article  CAS  PubMed  Google Scholar 

  36. Carmody E, Yeung E, McLoughlin M. Angiomyolipomas of the liver in tuberous sclerosis. Abdom Imaging 1994;19:537–539

    Article  CAS  PubMed  Google Scholar 

  37. Low VHS, Breidahl WH, Robbins PD. Hepatic angiomyolipoma. Abdom Imaging 1994;19:540–542

    Article  CAS  PubMed  Google Scholar 

  38. Linton PL, Ahn WS, Schwartz ME, et al. Angiomyolipoma of the liver: immunohistochemical study of a case. Liver 1991;11:158–161

    Article  CAS  PubMed  Google Scholar 

  39. Murakami T, Nakamura H, Hori S, et al. Angiomyolipoma of the liver: ultrasound CT, MR imaging, and angiography. Acta Radiol 1993;34:392–394

    CAS  PubMed  Google Scholar 

  40. Itai Y, Ohtomo K, Kokubo T, et al. CT of hepatic masses: significance of prolonged and delayed enhancement. AJR 1986;146:729–733

    Article  CAS  PubMed  Google Scholar 

  41. Yoshida H, Itai Y, Ohtomo K, et al. Small hepatocellular carcinoma and cavernous hemangioma: differentiation with dynamic FLASH MR imaging with Gd-DTPA. Radiology 1989;171:339–342

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ahmadi, T., Itai, Y., Takahashi, M. et al. Angiomyolipoma of the liver: significance of CT and MR dynamic study. Abdom Imaging 23, 520–526 (1998). https://doi.org/10.1007/s002619900391

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002619900391

Key words

Navigation