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A vector representation for amino acid sequences

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Abstract

A scheme for representing amino acids as vectors in the plane is presented and justified. The two dimensions of the plane are size and hydrophobicity. The vector representation is then applied to generate a consensus sequence for some sets of homologous proteins. A figure of merit for the degree of homology of a set of sequences results from the analysis. Some other applications of the scheme are considered also. This work grew from ideaseeds planted by Margaret Dayhoff's work in theAtlas of Protein Structure and Sequence. It is with gratitude that I dedicate this paper to her memory.

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Authors and Affiliations

  1. Department of Biochemistry, Texas A&M University, 77843, College Station, TX, U.S.A.

    Rosemarie Swanson

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  1. Rosemarie Swanson
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Swanson, R. A vector representation for amino acid sequences. Bltn Mathcal Biology 46, 623–639 (1984). https://doi.org/10.1007/BF02459507

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  • DOI: https://doi.org/10.1007/BF02459507

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