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Determination of some antipsychotropic and anticholinergic phenothiazine drugs by vanadium (V) titration

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Abstract

Three simple, rapid and accurate titrimetric procedures using ammonium metavanadate have been developed for the determination of six phenothiazine drags in pure form and in dosage forms. The procedures are based on the oxidation of phenothiazines in acid medium to colourless sulphoxides via orange or purple coloured intermediates. In the first method, phenothiazines are titrated directly in H2SO4-H3PO4 medium to a colourless end-point. In the second procedure, a known excess of oxidant is added and after a specified time, the residual oxidant is determined using standard ammonium ferrous sulphate titration. The third method employs electrometric end-point detection. The optimum reaction conditions and other analytical parameters are evaluated. The influence of the substrates commonly employed as excipients with phenothiazine drags has been studied. Statistical comparison of the results with those of an official method shows excellent agreement and indicates no significant difference in precision.

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References

  1. R. Cass, T. L. B. Spring,Br. J. Pharmac. Chemother. 1961,17, 442.

    Google Scholar 

  2. J. J. Lewis,An Introduction to Pharmacology, 3rd Edn. Churchill Livingstone, Edinburgh, 1965, pp. 251–261.

    Google Scholar 

  3. J. Karpinska, B. Starczewska, H. Puzanowska-Tarasiewicz,Anal. Sci. 1996,12, 161.

    Google Scholar 

  4. J. E. Fairbrother,Pharm. J. 1979,222, 271.

    Google Scholar 

  5. J. Milne,J. Pharm. Assoc. 1959,48, 117.

    Google Scholar 

  6. A. N. Nayak, Ranga Swamy, H. S. Yathirajan, P. G. Ramappa,Indian Drugs 1982,19, 202.

    Google Scholar 

  7. V. N. Pathak, I. C. Shukla, S. R. Shukla,Talanta 1982,29, 58.

    Google Scholar 

  8. A. Olech,Acta Pol. Pharm. 1973,30, 505.

    Google Scholar 

  9. B. Dembinski, K. Novakowski,Farm. Pol. 1974,30, 423.

    Google Scholar 

  10. O. Adam,Acta Pol. Pharm. 1972,29, 57.

    Google Scholar 

  11. A. Kurzava, L. Balcerikiewicz, A. Kryzminska,Chem. Anal. 1974,19, 333.

    Google Scholar 

  12. J. Blazek, M. Travnickova,Czesk. Farm. 1975,24, 100.

    Google Scholar 

  13. F. Albeit, H. Aftalion, R. Simionovici,Rev. Chim. (Bucharest)1968,19, 283.

    Google Scholar 

  14. The British Pharmacopoeia, HMSO, London, 1993.

  15. X. Y. Hu, Z. Z. Leng,Yaoxue Xuebao 1992,27, 283.

    Google Scholar 

  16. T. Peng, Z. Yang, R. Lu,Zhongguo. Yaouxe Zazhi 1990,25, 277.

    Google Scholar 

  17. D. De Orsi, L. Gagliardi, D. Tonelli,J. Pharm. Biomed. Anal. 1996,14, 1635.

    Google Scholar 

  18. R. D. Sayeed Ahmad, R. D. Sharma, I. C. Shukla,Talanta 1987,34, 296.

    Google Scholar 

  19. A. Banerjee, B. Hazra, H. Chatterjee, S. Banerjee, S. Dutt,Analyst 1989,114, 1151.

    Google Scholar 

  20. I. M. Kolthoff, R. Belcher,Volumetric Analysis, 1st Edn. Interscience Publishers, New York, 1957, pp. 634.

    Google Scholar 

  21. C. Channe Gowda, S. M. Mayanna,Indian Drugs 1994,31, 574.

    Google Scholar 

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Basavaiah, K., Krishnamurthy, G. Determination of some antipsychotropic and anticholinergic phenothiazine drugs by vanadium (V) titration. Mikrochim Acta 130, 197–201 (1999). https://doi.org/10.1007/BF01244928

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  • DOI: https://doi.org/10.1007/BF01244928

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