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Influence of dopamine on cerebral blood flow, and metabolism for oxygen and glucose under barbiturate administration in cats

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Summary

The effect of dopamine during barbiturate therapy was investigated in 29 cats including 5 sham-operated cats. According to Kiersey's classification of electro-encephalographic patterns, physiological variables, cerebral metabolic rates for oxygen and glucose, cerebral blood flow (CBF), and intracranial pressure (ICP), etc. were evaluated in each electro-encephalographic pattern. Oxygen-glucose index was calculated and used as an indicator for aerobic or anaerobic metabolism of glucose.

Group 1 (12 cats), to which only thiamylal was administered, maintained aerobic glycolysis due to a parallel reduction of cerebral metabolic rates for oxygen and glucose (about half of the initial value at Kiersey's fifth pattern) in spite of reduction of CBF and mean arterial blood pressure (MABP).

Group 2 (12 cats), to which dopamine was administered in addition to thiamylal due to a reduction of MABP, showed anaerobic glycolysis though MABP and CBF were maintained.

These findings are ascribed to an increase of cerebral metabolic rate for glucose up to 130% of the initial value though cerebral metabolic rate for oxygen decreased down to half of the initial value: The beneficial effect of barbiturate on cerebral metabolism was reduced by use of dopamine. ICP was reduced in both groups. Our result indicates that administration of extracellular fluid may be preferable for treatment of hypotension during barbiturate therapy than dopamine medication.

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References

  1. Astrup J, Symon L (1981) Thresholds in cerebral ischemia. The ischemic penumbra. Stroke 12: 723–725

    PubMed  Google Scholar 

  2. Brawley BW (1968) The pathophysiology of intracerebral steal following carbon dioxide inhalation, an experimental study. Scand J Clin Lab Invest 22 [Suppl 102]: 13B

    Google Scholar 

  3. Brown FD, Hanlon K, Nullan S (1978) Treatment of aneurysmal hemiplegia with dopamine and mannitol. J Neurosurg 49: 525–529

    PubMed  Google Scholar 

  4. Carter JP, Erspamer R, White WL, Yamagata S (1982) Cortical blood flow during craniotomy for aneurysm. Surg Neurol 17: 204–208

    PubMed  Google Scholar 

  5. Cusick JF, Myklebust J (1980) Continuous quantative local cerebral blood flow measurement. Calibration of thermal conductivity measurements by the hydrogen clearance method. Stroke 11: 661–664

    PubMed  Google Scholar 

  6. Edvinsson L, Hardebo JE, Harper AM, McCulloch J, Owman Ch (1977) Action of dopamine agonists on brain vessels in vitro and after in vivo microapplication. Acta Neurol Scand 64 [Suppl 56]: 350–351

    Google Scholar 

  7. Edvinsson L, Hardebo JE, McCulloch J, Owman Ch (1978) Effects of dopaminergic agonists and antagonists on isolated cerebral blood vessels. Acta Physiol Scand 104: 349–359

    PubMed  Google Scholar 

  8. Goldberg LI (1972) Cardiovascular and renal actions of dopamine: Potential clinical applications. Pharmacol Rev 24: 1–29

    PubMed  Google Scholar 

  9. Harvey SC (1985) Barbiturates. In: Gilman AG, Goodman LS, Rall TW, Murad F (eds) The pharmacological basis of therapeutics, 7th ed. Macmillan Publishing Co., Inc, New York, pp 351–360

    Google Scholar 

  10. Heiss WD, Rosner G (1983) Functional recovery of cortical neurons as related to degree and duration of ischemia. Ann Neurol 14: 294–301

    PubMed  Google Scholar 

  11. Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277: 93–96

    PubMed  Google Scholar 

  12. Kiersey DK, Bickford RG, Faulconer A Jr (1951) Electro-encephalographic patterns produced by thiopental sodium during surgical operations: description and classification. Br J Anaesth 23: 141–152

    PubMed  Google Scholar 

  13. Kosnik EJ, Hunt WE (1976) Postoperative hypertension in the management of patients with intracranial arterial aneurysms. J Neurosurg 45: 148–154

    PubMed  Google Scholar 

  14. McCulloch J, Harper AM (1977) Cerebral circulation: effect of stimulation and blockade of dopamine receptors. Am J Physiol 233: H222-H227

    PubMed  Google Scholar 

  15. McCulloch J, Teasdale G (1979) Effects of apomorphine upon local cerebral blood flow. Eur J Pharmacol 55: 99–102

    PubMed  Google Scholar 

  16. Michenfelder J (1974) The interdependency of cerebral functional and metabolic effects following massive doses of thiopental in the dog. Anesthesiology 41: 231–236

    PubMed  Google Scholar 

  17. Nakagawa Y, Kinomoto H, Abe H (1986) Effects of dopamine on cortical blood flow and somatosensory evoked potentials in the acute stages of cerebral ischemia. Stroke 17: 25–30

    PubMed  Google Scholar 

  18. Niimi T, Sawada T, Kuriyama Y, Naritomi H, Kamido H (1981) The effect of dopamine on cerebral circulation and metabolism in man. Jpn J Stroke 3: 318–325

    Google Scholar 

  19. Nordström CH, Messeter K, Sundbärg G, Schalen W, Werner M, Ryding E (1988) Cerebral blood flow, vasoactivity, and oxygen consumption during barbiturate therapy in severe traumatic lesions. J Neurosurg 68: 424–431

    PubMed  Google Scholar 

  20. Oldendorf WH (1971) Brain uptake of radiolabelled amino acids, amines, and hexoses after arterial injection. Am J Physiol 221: 1629–1639

    PubMed  Google Scholar 

  21. Safar P, Bleyaert A, Nemoto EM, Moossy J, Snyder JV (1978) Resuscitation after global brain ischemia-anoxia. Crit Care Med 6: 215–227

    PubMed  Google Scholar 

  22. Samson DS, Beyer CM (1980) Thiopental coma in the treatment of vasospasm-induced cerebral ischemia/infarction. In: Wilkins RH (ed) Cerebral arterial spasm (Proceedings of the second international workshop). Williams and Wilkins, Baltimore, pp 634–636

    Google Scholar 

  23. Sato M, Tanaka S, Suzuki K, Kohama A, Fujii C (1989) Complication associated with barbiturate therapy. Resuscitation 17: 233–241

    PubMed  Google Scholar 

  24. Sharkey J, McCulloch J (1985) Relationship between local cerebral blood flow and glucose utilization with selective dopamine receptor agonists. J Cereb Blood Flow Metab 5 [Suppl 1]: 537–538

    PubMed  Google Scholar 

  25. Sharkey J, McCulloch J (1986) Dopaminergic mechanism in the regulations of cerebral blood flow and metabolism: role of different receptor subtypes. In: Owman C, Hardebo JE (eds) Neural regulation of brain circulation. Elsevier Science Publishers B.V., pp 111–127

  26. Tanaka K, Greenberg JH, Gonatas NK, Reivich M (1985) Regional flow-metabolism couple following middle cerebral artery occlusion in cats. J Cereb Blood Flow Metab 5: 241–252

    PubMed  Google Scholar 

  27. Tuor UI, Edvinsson L, McCulloch J (1986) Catecholamines and the relationship between cerebral blood flow and glucose use. Am J Physiol 251: H824–833

    PubMed  Google Scholar 

  28. von Essen C (1974) Effects of dopamine on the cerebral blood flow in the dog. Acta Neurol Scand 50: 39–52

    PubMed  Google Scholar 

  29. von Essen C, Zervas NT, Brown DR, Koltun WA, Pickren KS (1980) Local cerebral blood flow in the dogs during intravenous infusion of dopamine. Surg Neurol 13: 181–188

    PubMed  Google Scholar 

  30. Ward JD, Becker DP, Miller JD, Choi SC, Marmarou A, Wood C, Newlon PG, Keenan R (1985) Failure of prophylactic barbiturate coma in the treatment of severe head injury. J Neurosurg 62: 383–388

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, Kinki University Medical School, Osaka, Japan

    M. Sato, K. Niiyama, R. Kuroda & M. Ioku

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  1. M. Sato
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  2. K. Niiyama
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  3. R. Kuroda
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  4. M. Ioku
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Sato, M., Niiyama, K., Kuroda, R. et al. Influence of dopamine on cerebral blood flow, and metabolism for oxygen and glucose under barbiturate administration in cats. Acta neurochir 110, 174–180 (1991). https://doi.org/10.1007/BF01400687

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