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Levels of immunoreactive cysteinyl-leukotrienes in CSF after subarachnoid haemorrhage correlate with blood flow-velocity in TCD

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Summary

Lipid peroxidation and enhanced arachidonic acid metabolism is activated after blood-brain cell contact. Previous studies have indicated that cysteinyl-leukotrienes (cys-LT) have the capacity to constrict arterial vessels in vivo and in vitro suggesting their involvement in the pathogenesis of cerebral vasospasm. The purpose of this study was to measure the amount of cyst-LT in the cerebro-spinal fluid (CSF) in correlation with transcranial Doppler findings (TCD) in patients with aneurysmal subarachnoid haemorrhage (SAH). In all patients early surgery was performed. In the first cisternal CSF-sample which was already collected intra-operatively an initial peak of cys-LT was detected, followed by decreasing amounts of cys-LT during the next 5 days. The CSF-levels of immunoreactive cys-LT were significantly higher in those patients who showed signs of vasospasm on transcranial Doppler sonography (TCD) (p < 0.001). Normalization of TCD values was accompanied by decreasing levels of CSF-cys-LT. We found a significant correlation between the amounts of immunoreactive cys-LT in cerebrospinal fluid and cerebral vasospasm measured by TCD.

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References

  1. Asano T, Watanabe T, Takakura K, Sano K, Shimizu T (1988) Activation of the lipoxygenase pathway following subarachnoid hemorrhage: its relevance to cerebral vasospasm. In: Wilkins RH (ed) Cerebral vasospasm. Raven, New York, pp 297–302

    Google Scholar 

  2. Chan PH, Fishman RA, Caronna J (1983) Induction of brain edema following intracerebral injection of arachidonic acid. Ann Neurol 13: 625–633

    PubMed  Google Scholar 

  3. Dempsey RJ, Roy MW, Cowen DE (1986) Lipoxygenase metabolites of arachidonic acid and the development of ischaemic cerebral oedema. Neurol Res 8: 53–56

    PubMed  Google Scholar 

  4. Findlay JM, Macdonald RL, Weir BKA (1991) Current concepts of pathophysiology and management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Cerebrovasc Brain Metab Rev 3: 336–361

    PubMed  Google Scholar 

  5. Fisher CM, Kistler JP, Davis JM (1980) Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomography scanning. Neurosurgery 6: 1–9

    PubMed  Google Scholar 

  6. Gaetani P, Marzatico F, Rodriguez Y, Baena R (1992) Ex vivo release of eicosanoids after aneurysmal subarachnoid hemorrhage: a preliminary experience in humans. Acta Neurol Scand 86: 184–189

    PubMed  Google Scholar 

  7. Hagen AA, White RP, Robertson JT (1979) Synthesis of prostaglandins and thromboxane B2 by cerebral arteries. Stroke 10: 306–309

    PubMed  Google Scholar 

  8. Harders A (1986) Neurosurgical applications of transcranial Doppler sonography. Springer, Wien New York

    Google Scholar 

  9. Hubschmann OR, Nathanson DC (1985) The role of calcium and cellular membrane dysfunction in experimental trauma and subarachnoid hemorrhage. J Neurosurg 62: 698–703

    PubMed  Google Scholar 

  10. Hunt WE, Hess RM (1968) Surgical risk as related to time of intervention in the repair of intracranial aneurysm. J Neurosurg 28: 14–20

    PubMed  Google Scholar 

  11. Kassell NF, Sasaki T, Colohan ART, Nazar G (1985) Cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Stroke 16: 562–572

    PubMed  Google Scholar 

  12. Kiwak KJ, Moskowitz MA, Levine L (1985) Leukotriene production in gerbil brain after ischemic insult, subarachnoid hemorrhage, and concussive injury. J Neurosurg 62: 865–869

    PubMed  Google Scholar 

  13. Kobayashi H, Ide H, Handa Y, Aradachi H, Arai Y, Kubota T (1992) Effect of leukotriene antagonist on experimental delayed cerebral vasospasm. Neurosurgery 31: 550–556

    PubMed  Google Scholar 

  14. Kontos HA, Wei EP, Ellis EF (1981) Prostaglandins in physiological and in certain pathological responses of the cerebral circulation. Fed Proc 40: 2326–2330

    PubMed  Google Scholar 

  15. Leslie JB, Wilkins WD (1985) Eicosanoids in the central nervous system. J Neurosurg 63: 659–668

    PubMed  Google Scholar 

  16. Moskowitz MA, Kiwak KJ, Hekimian K, Levine L (1984) Synthesis of compounds with properties of leukotrienes C4 and D4 in gerbil brains after ischemia and reperfusion. Science 224: 886–889

    PubMed  Google Scholar 

  17. Piper PJ, Samhoun MN (1987) Leukotrienes. Br Med Bull 43: 297–311

    PubMed  Google Scholar 

  18. Paoletti P, Gaetani P, Grignani G, Pacchiarini L, Silvani V, Rodriguez Y, Baena R (1988) CSF leukotriene following sub-arachnoid hemorrhage. J Neurosurg 69: 488–493

    Google Scholar 

  19. Rosenblum WI (1985) Constricting effect of leukotrienes on cerebral arterioles of mice. Stroke 16: 262–263

    PubMed  Google Scholar 

  20. Samuelsson B, Dahlen SE, Lindgren JA, Rouzer CA, Serhan CN (1987) Leukotrienes and lipoxins: structures, biosynthesis and biological effects. Science 237: 1171–1176

    PubMed  Google Scholar 

  21. Schweitzer P, Madamba S, Siggins GR (1990) Arachidonic acid metabolites as mediators of somastatin-induced increase of neuronal M-current. Nature 346: 464–467

    PubMed  Google Scholar 

  22. Siesjö BK, Wieloch T (1983) Prostaglandins and the cerebral circulation. Adv Prost Thrombox Leuk Res 12: 339–344

    Google Scholar 

  23. Shimizu T, Watanabe T, Asano T, Seyama Y, Takakura K (1988) Activation of the arachidonate 5-lipoxygenase pathway in the canine basilar artery after experimental subarachnoid hemorrhage. J Neurochem 51: 1126–1131

    PubMed  Google Scholar 

  24. Simmet T, Seregi A, Herting G (1987) Formation of sulphido-peptide-leukotrienes by tissue of spontaneously convulsing gerbils. Neuropharmacology 26: 107–110

    PubMed  Google Scholar 

  25. Simmet T, Luck W, Winking M, Delank WK, Peskar BA (1990) Identification and characterization of cysteinyl-leuko-triene formation in tissue slices from human intracranial tumors: evidence for their biosynthesis under in vivo conditions. J Neurochem 54: 209–2099

    Google Scholar 

  26. Simmet T, Peskar BA (1990) Lipoxygenase products of poly-unsaturated fatty acid metabolism in the central nervous system: biosynthesis and putative functions. Pharmacol Res 22: 667–682

    PubMed  Google Scholar 

  27. Tagari P, du Boulay GH, Aitken V (1983) Leukotriene D4 and the cerebral vasculature in vivo and in vitro. Prostaglandins Leukot Med 11: 281–297

    PubMed  Google Scholar 

  28. Watanabe T, Asano T, Shimizu T, Seyama Y, Takakura K (1988) Participation of lipoxygenase products from arachidonic acid in the pathogenesis of cerebral vasospasm. J Neurochem 50: 1145–1150

    PubMed  Google Scholar 

  29. Weir B, Grace M, Hansen J, Rothberg C (1978) Time course of vasospasm in man. J Neurosurg 48(2): 173–178

    PubMed  Google Scholar 

  30. Winking M, Lausberg G, Simmet T (1992) Malignancy dependent formation of cysteinyl-leukotrienes in human brain tumor tissues and its detection in urine. In: Piscol K, Brock M, Klinger M (eds) Advances in neurosurgery, Vol 20. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  31. Winking M, Boeker DK, Simmet T (1995) Blood-brain cell contact triggers leukotriene formation in brain cells via thrombin. J Cereb Blood Flow Metab 15 [Suppl 1]: 700

    Google Scholar 

  32. Winking M, Heldt RM, Simmet T (1996) Thrombin is the stimulus liable for activation of the cerebral 5-lipoxygenase pathway during blood-brain cell contact. J Cereb Blood Flow Metab 16: 737–745

    PubMed  Google Scholar 

  33. Yokota M, Tani E, Maeda Y (1987) Effect of 5-lipoxygenase inhibitor on experimental delayed cerebral vasospasm. Stroke 18: 512–518

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Neurosurgical Clinic, Justus-Liebig University Giessen, Federal Republic of Germany

    M. Winking M.D., H. W. Müller, W. Deinsberger, A. Joedicke & D. K. Boeker

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  1. M. Winking M.D.
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  2. H. W. Müller
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  3. W. Deinsberger
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  4. A. Joedicke
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  5. D. K. Boeker
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Winking, M., Müller, H.W., Deinsberger, W. et al. Levels of immunoreactive cysteinyl-leukotrienes in CSF after subarachnoid haemorrhage correlate with blood flow-velocity in TCD. Acta neurochir 139, 764–769 (1997). https://doi.org/10.1007/BF01420051

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