Summary
The uptake of labelled uridine is reduced in the whole ischaemic hemispheres of gerbils subjected to unilateral carotid artery occlusion. Following circulatory restoration, brain structures that had an ischaemic insult of moderate intensity exhibit a progressively increased uptake. However, during reperfusion there is a tendency towards a clear cut definition of dead zones. This progression of the lesions seems to be related to a maturation phenomenon occurring in areas with an irreversible damage at the end of the ischaemic period.
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Blaisdell, W. F., Clauss, R. H., Galbraith, J. G., Imparato, A. M., Wylie, E. J., Joint study of extracranial arterial occlusion. IV. A review of surgical considerations. J.A.M.A.209 (1969), 1889–1895.
Dodson, R. F., Chu, L. W. F., Welch, K. M. A., Achar, V. S., Acute tissue response to cerebral ischemia in the gerbil. An ultrastructural study. J. Neurol. Sci.33 (1977), 161–170.
Fog, R., Pakkenberg, H., Relative uptake of tritiated uridine in various brain areas in the mouse. J. Neurochem.27 (1976), 1261–1262.
Fraser, R. A. R., Yoshida, S., Patterson, R. H., Focal cerebral ischemia and reperfusion. The golden period. Neurosurgery1 (1977), 66–67.
Harrison, M. J. G., Ross Russell, R. W., Effect of dexamethasone on experimental cerebral infarction in the gerbil. J. Neurol. Neurosurg. Psych.35 (1972), 520–521.
Irino, T., Taneda, M., Minami, T., Sanguineous cerebrospinal fluid in recanalized cerebral infarction. Stroke8 (1977), 22–24.
Ito, U., Spatz, M., Walker, J. T., Klatzo, I., Experimental cerebral ischemia in mongolian gerbils. I. Light microscopic observations. Acta Neuropath. (Berlin)32 (1975), 209–223.
Kahn, K., The natural course of experimental cerebral infarction in the gerbil. Neurology22 (1972), 510–515.
Klatzo, I., Pathophysiological aspects of cerebral ischemia. In: The nervous system, vol. 1, The basic neurosciences, pp. 313–332 (Tower, D. B., ed.). New York: Raven Press. 1975.
Levine, S., Payan, H., Effects of ischemia and other procedures on the brain and retina of the gerbil (Meriones unguiculatus). Exp. Neurol.16 (1966), 255–263.
Levine, S., Sohn, D., Cerebral ischemia in infant and adult gerbils. Arch. Path. (Chicago)87 (1969), 315–317.
Levy, D. E., Brierley, J. B., Communications between vertebro-basilar and carotid arterial circulations in the gerbil. Exp. Neurol.45 (1974), 503–508.
Morrell, R. M., Defective protein metabolism in ischemic gerbil brain. Acta Neurol. Scand.56, suppl. 64 (1977), 368–369.
Morrell, R. M., Gaudet, R., Welch, K. M. A., Increased RNAse sensitivity is a cause of cerebral polysome disruption in the ischemic gerbil model. Stroke8 (1977), 133–133.
Mršulja, B. B., Lust, W. D., Mršulja, B. J., Passonneau, J. V., Klatzo, I., Post-ischemic changes in certain metabolites following prolonged ischemia in the gerbil cerebral cortex. J. Neurochem.26 (1976), 1099–1103.
Mršulja, B. B., Mršulja, B. J., Spatz, M., Ito, U., Walker, J. T., Klatzo, I., Experimental cerebral ischemia in mongolian gerbil. IV. Behaviour of biogenic amines. Acta Neuropath. (Berlin)36 (1976), 1–8.
Osburne, R. C., Halsey, J. H., Cerebral blood flow as a predictor of recovery from ischemia in the gerbil. Arch. Neurol. (Chicago)32 (1975), 457–461.
Payan, H. M., Conard, J. R., Carotid ligation in gerbils. Influence of age, sex, and gonads. Stroke8 (1977), 194–197.
Schwartz, J. P., Mršulja, B. B., Mršulja, B. J., Passonneau, W., Klatzo, I., Alterations of cyclic nucleotide-related enzymes and ATPase during unilateral ischemia and recirculation in gerbil cerebral cortex. J. Neurochem.27 (1976), 101–108.
Waltz, A. G., Pathophysiology of cerebral infarction. Clin. Neurosurg.23 (1976), 147–154.
Westergaard, E., Go, G., Klatzo, I., Spatz, M., Increased permeability of cerebral vessels to horseradish peroxidase induced by ischemia in mongolian gerbils. Acta Neuropath. (Berlin)35 (1976), 307–325.
Wylie, E. J., Hein, M. F., Adams, J. E., Intracranial hemorrhage following surgical revascularization for treatment of acute strokes. J. Neurosurg.21 (1964), 212–215.
Yanagihara, T., Cerebral ischemia in gerbils: differential vulnerability of protein, RNA and lipid syntheses. Stroke7 (1976), 260–263.
Yu, J. Y. L., Gorbman, A., Rapidity of distribution of [3H] uridine and its incorporation into RNA in various regions of adult rat brain following intraventricular injections. J. Neurochem.27 (1976), 1263–1265.
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De Riu, P.L., Orunesu, G., Pau, A. et al. Effect of reperfusion on the uptake of [3H] uridine in the gerbil brain after prolonged ischaemia. Acta neurochir 47, 253–260 (1979). https://doi.org/10.1007/BF01406408
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DOI: https://doi.org/10.1007/BF01406408