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Responses of isolated canine and simian basilar arteries to thiopentone by a newly designed pharmacological method for measuring vascular responsiveness

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Summary

The stainless steel cannula inserting method was modified for application to observe vascular responses to thiopentone in the isolated basilar arteries of the dog and monkey. In the dog, thiopentone (0.01–3 mg) induced a monophasic vasoconstriction in a dose-dependent manner. On the other hand, in the monkey, thiopentone (0.01–3 mg) showed a biphasic vascular response,i.e., an initial vasoconstriction followed by a vasodilatation in a dose-dependent manner. Thiopentone usually produced much more potent vasoconstriction in the dog than that in the monkey, while potassium chloride made little difference of vasoconstriction between the dog and monkey basilar arteries. These findings suggest that thiopentone exerts a direct constrictive effect on cerebral vessels, the actions of which decrease the total cerebral blood volume and the brain bulk, allowing a reduction in intracranial pressure.

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References

  1. Allen, G. S., Henderson, L. M., Chou, S. N., French, L. A., Cerebral arterial spasm. Part 1: In vitro contractile activity of vasoactive agents on canine basilar and middle cerebral arteries. J. Neurosurg.40 (1974), 433–441.

    PubMed  Google Scholar 

  2. Bevan, J. A., Osher, J. V., A direct method for recording tension changes in the wall of small blood vessels in vitro. Agents and Actions2 (1972), 257–260.

    PubMed  Google Scholar 

  3. Bohr, D. F., Goulet, P. L., Taquini, A. C., Jr., Direct tension recording from smooth muscle of resistance vessels from various organs. Angiology12 (1961), 478–485.

    PubMed  Google Scholar 

  4. Chiba, S., Tsukada, M., Effect of pH alterations on the vascular reactivity of dog isolated perfused mesenteric arteries. Japan. J. Pharmacol.34 (1984), 465–467.

    Google Scholar 

  5. Chiba, S., Tsukada, M., Comparison of the vascular responses of simian and canine mesenteric arteries to vasoactive substances. Japan. J. Pharmacol.35 (1984), 199–201.

    Google Scholar 

  6. Chiba, S., Tsukada, M., Potentiation of KCl-induced vasoconstriction by saponin treatment in isolated canine mesenteric arteries. Japan. J. Pharmacol.36 (1984), 535–537.

    Google Scholar 

  7. Chiba, S., Tsukada, M., Vasoconstrictor responses of isolated and perfused canine mesenteric arteries to alpha-adrenoceptor agonists. Arch. Int. Pharmacodyn.271 (1984), 241–248.

    PubMed  Google Scholar 

  8. Chiba, S., Tsukada, M., Vasoconstrictor responses induced by α-adrenoceptor agonists before and after removal of the endothelial cells of dog mesenteric arteries. J. Auton. Pharmac.4 (1984), 257–260.

    Google Scholar 

  9. Edvinsson, L., Nielsen, K. C., Owman, C., Influence of initial tension and changes in sensitivity during amine-induced contractions of pial arteries in vitro. Arch. Int. Pharmacodyn.208 (1974), 235–242.

    PubMed  Google Scholar 

  10. Edvinsson, L., McCulloch, J., Effects of pentobarbital on contractile responses of feline cerebral arteries. J. Cereb. Blood Flow Metabol.1 (1981), 437–440.

    Google Scholar 

  11. Hoff, J. T., Smith, A. L., Hankinson, H. L., Nielsen, S. L., Barbiturate protection from cerebral infarction in primates. Stroke6 (1975), 28–33.

    PubMed  Google Scholar 

  12. Hongo, K., Chiba, S., A new method for measuring vascular responsiveness of relatively larger arteries of dogs. J. Pharmacol. Methods9 (1983), 83–90.

    PubMed  Google Scholar 

  13. Ito, T., Chiba, S., Vascular responses of isolated canine intermediate auricular artery to vasoactive substances. Arch. Int. Pharmacodyn.268 (1984), 225–231.

    PubMed  Google Scholar 

  14. Ito, T., Chiba, S., Responses of isolated canine intermediate auricular arteries to 5-hydroxytryptamine and methysergide. Eur. J. Pharmacol.104 (1984), 105–109.

    PubMed  Google Scholar 

  15. Kassell, N. F., Peerless, S. J., Drake, C. G., Boarini, D. J., Adams, H. P., Treatment of ischemie deficits from cerebral vasospasm with high dose barbiturate therapy. Neurosurgery7 (1980), 593–597.

    PubMed  Google Scholar 

  16. Kassell, N. F., Hitchon, P. W., Gerk, M. K., Sokoll, M. D., Hill, T. R., Alterations in cerebral blood flow, oxygen metabolism, and electrical activity produced by high dose sodium thiopental. Neurosurgery7 (1980), 598–603.

    PubMed  Google Scholar 

  17. Marín, J., Rico, M. L., Salaices, M., Interference of pentobarbitone with the contraction of vascular smooth muscle in goat middle cerebral artery. J. Pharm. Pharmacol.33 (1981), 357–361.

    PubMed  Google Scholar 

  18. Marín, J., Lobato, R. D., Rico, M. L., Salaices, M., Benitez, J., Effect of pentobarbital on the reactivity of isolated human cerebral arteries. J. Neurosurg.54 (1981), 521–524.

    PubMed  Google Scholar 

  19. Marsh, M. L., Marshall, L. F., Shapiro, H. M., Neurosurgical intensive care. Anesthesiology47 (1977), 149–163.

    PubMed  Google Scholar 

  20. Marshall, L. F., Shapiro, H. M., Rauscher, A., Kaufman, N. M., Pentobarbital therapy for intracranial hypertension in metabolic coma. Reye's syndrome. Crit. Care Med.6 (1978), 1–5.

    PubMed  Google Scholar 

  21. Marshall, L. F., Smith, R. W., Shapiro, H. M., The outcome with aggressive treatment in severe head injuries. Part I: The significance of intracranial pressure monitoring. J. Neurosurg.50 (1979), 20–25.

    PubMed  Google Scholar 

  22. Marshall, L. F., Smith, R. W., Shapiro, H. M., The outcome with aggressive treatment in severe head injuries. Part II: Acute and chronic barbiturate administration in the management of head injury. J. Neurosurg.50 (1979), 26–30.

    PubMed  Google Scholar 

  23. Michenfelder, J. D., Milde, J. H., Sundt, T. M., Jr., Cerebral protection by barbiturate anesthesia: Use after middle cerebral artery occlusion in Java monkeys. Arch. Neurol.33 (1976), 345–350.

    PubMed  Google Scholar 

  24. Miller, J. D., Barbiturates and raised intracranial pressure. Ann. Neurol.6 (1979), 189–193.

    PubMed  Google Scholar 

  25. Nielsen, K. C., Owman, C., Contractile response and amine receptor mechanisms in isolated middle cerebral artery of the cat. Brain Res.27 (1971), 33–42.

    PubMed  Google Scholar 

  26. Ohhashi, T., Azuma, T., Paradoxical relaxation of arterial strips induced by vasoconstrictive agents. Blood Vessels17 (1980), 16–26.

    PubMed  Google Scholar 

  27. Piatt, J. H., Schiff, S. J., High dose barbiturate therapy in neurosurgery and intensive care. Neurosurgery15 (1984), 427–444.

    PubMed  Google Scholar 

  28. Rockoff, M. A., Marshall, L. F., Shapiro, H. M., High-dose barbiturate therapy in humans: A clinical review of 60 patients. Ann. Neurol.6 (1979), 194–199.

    PubMed  Google Scholar 

  29. Shapiro, H. M., Galindo, A., Wyte, S. R., Harris, A. B., Rapid intraoperative reduction of intracranial pressure with thiopentone. Brit. J. Anaesth.45 (1973), 1057–1062.

    PubMed  Google Scholar 

  30. Shapiro, H. M., Wyte, S. R., Loeser, J., Barbiturate-augmented hypothermia for reduction of persistent intracranial hypertension. J. Neurosurg.40 (1974), 90–100.

    PubMed  Google Scholar 

  31. Smith, A. L., Hoff, J. T., Nielsen, S. L., Larson, C. P., Barbiturate protection in acute focal cerebral ischemia. Stroke5 (1974), 1–7.

    PubMed  Google Scholar 

  32. Sokoll, M. D., Kassell, N. F., Davies, L. R., Large dose thiopental anesthesia for intracranial aneurysm surgery. Neurosurgery10 (1982), 555–562.

    PubMed  Google Scholar 

  33. Sugita, K., Kobayashi, S., Inoue, T., Takemae, T., Characteristics and use of ultra-long aneurysm clips. J. Neurosurg.60 (1984), 145–150.

    PubMed  Google Scholar 

  34. Tsuji, T., Chiba, S., Potentiating effect of methysergide on norepinephrine-induced constriction of the isolated internal carotid artery of the dog. Japan. J. Pharmacol.34 (1984), 95–100.

    Google Scholar 

  35. Uchida, E., Bohr, D. F., Hoobler, S. W., A method for studying isolated resistance vessels from rabbit mesentery and brain and their responses to drugs. Circ. Res.21 (1967), 525–536.

    PubMed  Google Scholar 

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Tsuji, T., Chiba, S. Responses of isolated canine and simian basilar arteries to thiopentone by a newly designed pharmacological method for measuring vascular responsiveness. Acta neurochir 80, 57–61 (1986). https://doi.org/10.1007/BF01809558

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