Summary
Over the past 10 years we have experienced 33 cases of von Recklinghausen's disease, among whom 5 were cases of multiple (3 or more) brain tumours. In the past we have extirpated multiple tumours in a one-stage operation, but the results were poor. Recently, we have done multi-stage operation in two cases thought to require surgical treatment and have obtained satisfactory results.
We have discussed the autopsy results of our own case of multiple neurinomas and meningiomas and have reviewed the 44 reported cases of von Recklinghausen's disease in whom the presence of three or more brain tumours had been confirmed at surgery or autopsy.
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References
Akagi I, Nakatani J, Ikushio Yet al (1973) Primary multiple brain tumors — a case combined with left acoustic neurinoma and lateral ventricle meningioma. Brain and Nerve 25: 1823–1827
Arai H, Chichibu M, Ikuta Fet al (1969) An autopsy case combined with multiple gliomas, meningiomas and neurinomas and its genesis. Brain and Nerve 21: 1241–1249
Canale D, Bebin J, Knighton RS (1964) Neurologic manifestation of von Recklinghausen's disease of the nervous system. Confin Neurol 24: 359–403
Davidoff LM, Martin J (1955) Hereditary combined neurinomas and meningiomas. J Neurosurg 12: 375–384
Hitselberger WE, Hughes RL (1968) Bilateral acoustic tumors and neurofibromatosis. Arch Otolaryng 88: 700–711
Ishihara Y, Hoda S, Tohyama M (1964) A case of von Recklinghausen's disease combined with tumor of nervous system. Prog Neuro Res 8: 87–88
Kameyama S, Arai H, Ueki Yet al (1979) Primary multiple brain tumors combined with other kind of tumors. Brain and Nerve 31: 703–712
Kitamura K, Nakamura N, Terao Het al (1965) Primary multiple brain tumors. Brain and Nerve 17: 109–117
Lichtenstein BW (1949) Neurofibromatosis (von Recklinghausen's disease of the nervous system) analysis of the total pathologic picture. Arch Neurol Psychiatry 62: 822–839
Momoi I, Shimada S (1954) An autopsy case of neurofibromatosis with multiple meningiomas. Nippon Byori Gakkai Zasshi 43: 252–253
Nagashima C, Nakashio K, Fujino S (1961) Multiple primary brain tumors, a case combined with glioma and meningioma. Brain and Nerve 13: 967–975
Naota Y, Tagai M, Nagashima Ket al (1966) An autopsy case of acoustic neurinoma combined with dysplasia and multiple meningiomas. Igaku No Ayumi 56: 653–655
Nakamura N, Makibuchi T, Ogawa Het al (1976) An autopsy case combined with neurinoma, meningioma, glioma and angiomatous pathological change. Kitanihon Igaku Zasshi 26: 344–346
O'Connel JE (1961) Intracranial meningiomata associated with other tumors involving the central nervous system. Brit J Surg 48: 373–383
Penfield W, Young AW (1940) The nature of von Reckling/hausen's disease and the tumors associated with it. Arch Neurol Psychiatry 23: 320–344
Pearse J (1967) The central nervous system pathology in multiple neuromatosis. Neurology 17: 691–697
Rodriguez HA, Berthrong M, Spring C (1966) Multiple primary intracranial tumors in von Recklinghausen's neurofibromatosis. Arch Neurol 14: 467–475
Sachs E (1966) The occurrence of different type of brain tumors in one patient. Surg Gynecol Obstet 62: 757–759
Turner OA, Garden WJ (1938) Familial involvement of the nervous system by multiple tumors of the sheaths and enveloping membranes: Hereditary, clinical and pathological study of central and peripheral neurofibromatosis. Am Cancer 32: 339–360
Togashi O, Kan T, Ueda Yet al (1978) A case of von Recklinghausen's disease of a child combined with multiple neurofibromas and intraventricular meningiomas. Clin Neurol 18: 295
Terao H, Tsukamoto Y, Sano K (1967) Von Recklinghausen's disease and brain tumors. Brain and Nerve 19: 1235–1245
Worster-Drought C, Dickson WE, McMenemey WH (1937) Multiple meningeal and perineural tumors with analogous changes in the glia and ependymoma (Neurofibromatosis). Brain 60: 85–117
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Mashiyama, S., Mori, T., Seki, H. et al. Multiple brain tumours with von Recklinghausen's disease. Acta neurochir 84, 29–35 (1987). https://doi.org/10.1007/BF01456347
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DOI: https://doi.org/10.1007/BF01456347