Summary
Glucocorticoid receptors were measured in tissue samples from 12 patients with glioblastoma multiforme. The receptor was found in all patients. The concentration of glucocorticoid receptor was found to be high in the periphery of the tumour, low in the surrounding brain tissue and low in the central part of the tumour in 6 of the patients. The possible role of the glucocorticoid receptor distribution in relation to growth regulation is discussed. A decreasing receptor concentration found at reoperation in two patients indicates a possible antineoplastic effect of high dose methylprednisolone pulse therapy on glucocorticoid receptor positive glioblastomas.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Becker PB, Gloss B, Schmid Wet al (1986) In vivo protein-DNA interactions in a glucocorticoid response require the presence of the hormone. Nature 324: 686–688
Bloom I, Matulich DT, Law NCet al (1980) Nuclear binding of glucocorticoid receptors: relations between cytosol bindings, activation and the biological response. J Steroid Biochemistry 12: 175–184
Bortkowski H (1980) Intracranial edemagenisis. Progr Exp Tumour Res 1: 179–190
Braunschweiger PG, Ting HLet al (1983) Correlation between glucocorticoid receptor content and the antiproliferative effect of dexamethasone in experimental Solid Tumours. Cancer Res 43: 4757–4761
Bradford MM, Schiffer LM (1976) Protein measurement by biorad method. Anal Biochem 72: 248–254
Ellemann K, Bollinger Bet al (1988) Continuously high dose Methylprednisolone pulse therapy in glucocorticoid receptor positive glioblastoma multiforme. Acta Neurol Scand 77: 74–77
E.O.R.T.C (1973) Steroid receptor techniques. Eur J Cancer 9: 379–381
Freshney RJ, Sherry A, Hessauzadah Met al (1980) Control of cell proliferation in human glioma by glucocorticoids. Br J Cancer 41: 857–866
Freshney RJ (1984) Effects of glucocorticoids on glioma cells in culture. Exp Cell Biol 52: 286–292
Green IB, Byar DP, Walker MDet al (1983) Comparisons of carmustine, procarbazine and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma. Cancer Treat Rep 67: 121–132
Glumer M, Freshney RJ, Morgan Det al (1977) Effects of dexamethasone and betamethasone on in vitro cultures from human astrocytoma. Br J Cancer 35: 439–447
Leignarda R, Sierra J, Pardal Get al (1985) Effect of large doses of methylprednisolone on supratentorial intracranial tumours. Eur Neurol 24: 23–32
Munson PJ (1984) Heterogeneous receptors and binding curve analysis in neurobiology. In: Brain receptor methodologies. Academic Press, New York, London, pp 33–48
Müller W, Kretzschmar K, Schicketanz R-H (1984) CT-analysis of cerebral tumours under steroid therapy. Neuroradiology 26: 293–298
Poisson M, Pertuiset BF, Hawo J-Jet al (1983) Steroid hormone receptors in human meningiomas, gliomas and brain metastases. J Neuro-Oncology 1: 179–189
Reulen HJ, Hajidimos Aet al (1973) Steroids in the treatment of brain edema. In: Schürmann K, Brock Met al (eds) Brain edema. Pathophysiology and therapy. Cerebello-pontine angle tumors. Advances in neurosurgery, vol 1. Springer, Berlin Heidelberg New York, pp 92–99
Rengachary JJ, Filzer LL (1981) A study of dexamethasone receptor protein in human gliomas. J Surg Res 31: 447–455
Saponsky RM, Mc Even BJet al (1983) Quantitative autoradiography of [3H]-corticosterone receptors in rat brain. Brain Res 271: 331–335
SilverswÄrd C, Skoog L, Humla Jet al (1980) Intratumoral variation of cytoplasmic and nuclear oestrogen receptor concentrations in human mammary carcinoma. Eur J Cancer 16: 59–65
Warenborg M (1975) Radioautographic study of the rat brain after injection of [1,2−3H] corticosterone. Brain Res 89: 61–70
Wilson CB, Barker M, Hoskino Tet al (1912) Stereoidinduced inhibition of growth in glial tumors: a kineticanalysis. In: Neulen HJ, Schurmann K (eds) Steroids and brain edema. Springer, Berlin Heidelberg New York
Yamashita T, Kuwatara T (1983) Estimation of rate of growth of malignant brain tumours by computed tomography scanning. Surg Neurol 20: 464–470
Yu Z-Y, Wrange ö, Böethius Jet al (1981) A study of glucocorticoid receptors in intracranial tumors. J Neurosurg 55: 757–760
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ellemann, K., Christensen, L., Gjerris, F. et al. Glucocorticoid receptors in glioblastoma multiforme: A new approach to antineoplastic glucocorticoid therapy. Acta neurochir 93, 6–9 (1988). https://doi.org/10.1007/BF01409894
Issue Date:
DOI: https://doi.org/10.1007/BF01409894