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TJS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effects in rats

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Summary

We evaluated the effect of TJS-010, a new prescription of oriental medicine, on hypothermia and flat body posture in rats, induced by activation of serotonin (5-HT)-1A receptors by (±)-8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT). Hypothermia was induced by 8-OH-DPAT in a dose and time-dependent manner. The hypothermia induced by O.1mg/kg 8-OH-DPAT was enhanced by 500 and 750mg/kg of TJS-010. At the concentration of O.1 mg/kg, 8-OH-DPAT also produced flat body posture in rats, and 750mg/ kg TJS-010 increased the flat body posture. These results suggest that TJS-010 facilitates the 5-HT-1A receptors in the central nervous system.

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Abbreviations

8-OH-DPAT :

(±)-8-hydroxy-2-(di-N-propylamino)tetralin

5-HT :

5-hydroxy-tryptamine(serotonin)

ACTH :

adrenocorticotropic hormone

CNS :

central nervous system

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Author notes

  1. S. Yamawaki

    Present address: Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Hiroshima, Japan

Authors and Affiliations

  1. Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Hiroshima, Japan

    A. Kagaya, A. J. Tanra, H. Shinno, A. Kugaya, M. Muraoka, T. Oyamada & Y. Uchitomi

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  1. A. Kagaya
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  2. A. J. Tanra
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  3. H. Shinno
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  4. A. Kugaya
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  5. M. Muraoka
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  6. T. Oyamada
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  7. Y. Uchitomi
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Kagaya, A., Tanra, A.J., Shinno, H. et al. TJS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effects in rats. J. Neural Transmission 103, 69–75 (1996). https://doi.org/10.1007/BF01292617

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  • DOI: https://doi.org/10.1007/BF01292617

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