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Effect of interferon-α on DOI-induced wet-dog shakes in rats

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Summary

Acute (1h) intraperitoneal (ip) treatment with interferon (IFN)-α-2a (300IU/g) significantly inhibited wet-dog shakes (WDS) induced by (±)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI; 0.5, 1.0mg/kg), which is mediated by serotonin (5-hydroxytryptamine; 5-HT)2 receptor in rats. IFN-α did not affect spontaneous locomotion. The inhibition of DOI (0.5mg/kg)-induced WDS by IFN-α was dose (90–300 IU/g)- and time (1–6 h)-dependent, and was prevented by 30 min pretreatment with naltrexone (NLTX; 1.0mg/kg, ip), an opioid receptor antagonist. Acute (1h) intracerebroventricular (icv) treatment with IFN-α (1,500IU/rat) also inhibited DOI (0.5mg/kg)-induced WDS, and the effect was blocked by NLTX (50μg/rat, icv). These results suggest that IFN-α may modulate 5-HT2 receptor-mediated behavior through opioid receptors in the central nervous system.

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Abbreviations

CNS :

central nervous system

DOI :

(±)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane

5-HT :

5-hydroxytryptamine (serotonin)

icv :

intracerebroventricular

IFN :

interferon

ip :

intraperitoneal

IU :

international unit

NLTX :

naltrexone

sc :

subcutaneous

WDS :

wet-dog shakes

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Author notes

  1. S. Yamawaki

    Present address: Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Hiroshima

Authors and Affiliations

  1. Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Hiroshima

    A. Kugaya, A. Kagaya & N. Yokota

  2. Psycho-Oncology Division, National Cancer Center Research Institute, East, Kashiwa, Japan

    Y. Uchitomi

Authors
  1. A. Kugaya
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  2. A. Kagaya
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  3. Y. Uchitomi
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  4. N. Yokota
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  5. S. Yamawaki
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Kugaya, A., Kagaya, A., Uchitomi, Y. et al. Effect of interferon-α on DOI-induced wet-dog shakes in rats. J. Neural Transmission 103, 947–955 (1996). https://doi.org/10.1007/BF01291785

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