Summary
Rats who where administered apomorphine seven days after termination of chronic treatment with haloperidol had significantly (59%) lower level of brain HVA than saline control rats. This finding is consistent with the behavioral evidence suggesting supersensitivity of post-synaptic dopamine receptors after termination of chronic haloperidol.
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This work was begun when all authors were associated with the Illinois State Psychiatric Institute.
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Smith, R.C., Narasimhachari, N. & Davis, J.M. Increased effect of apomorphine on homovanillic acid in rats terminated from chronic haloperidol. J. Neural Transmission 42, 159–162 (1978). https://doi.org/10.1007/BF01675355
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DOI: https://doi.org/10.1007/BF01675355